EVALUATION OF ABORTIFACIENT ACTIVITY OF ROOT OF LAWSONIA INERMIS THROUGH INSILICO DOCKING

Authors

  • Rajeswari J Annamalai university
  • Rani S

Abstract

root of L. inermis with progesterone receptor through in silico docking.
Methods: The molecular docking analysis of the 41 compounds which is derived from L. inermis with the progesterone receptor was carried out
using the GOLD software. Further, the plant undergoes absorption, distribution, metabolism and excretion (ADME) analysis, and pharmacokinetic
parameters have been done.
Results: The results showed that D-allose is having the highest binding affinity with the progesterone receptor having a GOLD score of 32.08. D-allose
present in henna inhibits the activity of progesterone and induces abortion, and it also satisfies ADME parameters.
Conclusion: The findings concluded that L. inermis root exhibit abortifacient activity and further studies are suggested to isolate the active principles
responsible for the activity.

Keywords: Lawsonia inermis, Progesterone receptor, D-Allose, Abortifacient activity, GOLD.

References

Garfield RE, Kannan MS, Daniel EE. Gap junction formation in

myometrium: Control by estrogens, progesterone, and prostaglandins.

Am J Physiol 1980;238(3):C81-9.

Cragg GM, Newman DJ, Snader KM. Natural products in drug

discovery and development. J Nat Prod 1997;60(1):52-60.

Padma TV. Ayurveda. Nature 2005;436(7050):486.4. Lavhate MS, Mishra SH. A review on nutritional and therapeutic

potential of Ailanthus excels. Pharmacog Rev 2007;1(1):105-13.

Gupta AK. Quality standards of Indian medicinal plants. Indian Counc

Med Res 2003;1:123-9.

Sastri BN. The Wealth of India: Raw Materials. 2nd ed. Vol. 6 (L-M).

New Delhi: CSIR; 1997. p. 47-50.

Perun T, Propst CL. Computer Aided Drug Design. New York: Marcel

Dekker; 1989. p. 2-4.

Berger SI, Iyengar R. Network analyses in systems pharmacology.

Bioinformatics 2009 1;25:2466-72.

Cheng F, Li W, Zhou Y, Shen J, Wu Z, Liu G, et al. AdmetSAR: A

comprehensive source and free tool for assessment of chemical

ADMET properties. J Chem Inf Model 2012 26;52:3099-105.

Balakin KV, Ivanenkov YA, Savchuk NP, Ivashchenko AA, Ekins S.

Comprehensive computational assessment of ADME properties using

mapping techniques. Curr Drug Discov Technol 2005;2(2):99-113.

Published

2015-05-01

How to Cite

J, R., and R. S. “EVALUATION OF ABORTIFACIENT ACTIVITY OF ROOT OF LAWSONIA INERMIS THROUGH INSILICO DOCKING”. Asian Journal of Pharmaceutical and Clinical Research, vol. 8, no. 3, May 2015, pp. 146-50, https://innovareacademics.in/journals/index.php/ajpcr/article/view/5160.

Issue

Section

Original Article(s)