• Suneel Kumar A Acharya Nagarjuna University
  • Venkatarathanamma V
  • Naga Saibabu V
  • Seetha Ram K


Objective: To evaluate and compare the in vivo antipyretic activity of the methanolic extracts of selected three Annona plant leaves.
Methods: The acute oral toxicity determined by OECD class method and the in vivo antipyretic activity was determined by brewer's yeast induced
pyrexia method.
Results: The results showed that the methanolic extract of leaves of Annona plants are non-toxic and possessed significant antipyretic effect which
may be attributed to the presence of flavonoids and saponins in the extracts.
Conclusion: This study provides evidences for the antipyretic activity of Annona squamosa, Annona reticulata and Annona muricata possess antipyretic
activity at the tested doses 100 and 200 mg/kg body weight without any side effects, which could partly contribute to its ethno medical use.

Keywords: Annona squamosa L, Annona reticulata L, Annona muricata L, Antipyretic activity, Brewer's yeast.

Author Biography

Suneel Kumar A, Acharya Nagarjuna University

Biochemistry Department


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How to Cite

Kumar A, S., V. V, N. S. V, and S. Ram K. “ANTIPYRETIC ACTIVITY OF ANNONA PLANTS LEAVES ON BREWER’S YEAST INDUCED FEBRILE RATS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 8, no. 3, May 2015, pp. 210-2,



Original Article(s)