ANTIPYRETIC ACTIVITY OF ANNONA PLANTS LEAVES ON BREWER'S YEAST INDUCED FEBRILE RATS
Objective: To evaluate and compare the in vivo antipyretic activity of the methanolic extracts of selected three Annona plant leaves.
Methods: The acute oral toxicity determined by OECD class method and the in vivo antipyretic activity was determined by brewer's yeast induced
Results: The results showed that the methanolic extract of leaves of Annona plants are non-toxic and possessed significant antipyretic effect which
may be attributed to the presence of flavonoids and saponins in the extracts.
Conclusion: This study provides evidences for the antipyretic activity of Annona squamosa, Annona reticulata and Annona muricata possess antipyretic
activity at the tested doses 100 and 200 mg/kg body weight without any side effects, which could partly contribute to its ethno medical use.
Keywords: Annona squamosa L, Annona reticulata L, Annona muricata L, Antipyretic activity, Brewer's yeast.
Deepak Kumar B, Rao VR, Devi MS, Chandrashekar B. Antipyretic activity of whole plant of in brewerâ€™s yeast induced hyperpyrexia rats. Int J Res Pharmacol Pharmacother 2012;1(1):14-7.
Guyton AC, Hall JE. Textbook of Medical Physiology. 9th ed. Philadelphia: W.B Saunders Company; 1998. p. 920-2.
Pasin JS, Ferreira AP, Saraiva AL, Ratzlaff V, Andrighetto R, Machado P, et al. Antipyretic and antioxidant activities of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles in rats. Braz J Med Biol Res 2010;43:1193-202.
Acute Oral Toxic Class Method Guideline 423 adopted 17.12.2001. Guidelines for the Testing of Chemicals Organisation for Economical Co â€“ Operation and Development (OECD), Paris.
Adams SS, Hebborn P, Nicholson JS. Some aspects of the pharmacology of ibufenac, a non-steroidal anti-inflammatory agent. J Pharm Pharmacol 1968;20(4):305-12.
Gupta MB, Nath R, Srivastava N. Anti-inflammatory and antipyretic activities of beta sitosterol. Int J Immunopharmacol 1996;18:693-700.
Bouic PJ, Lamprecht JH. Plant sterols and sterolins: A review of their immune-modulating properties. Altern Med Rev 1999;4(3):170-7.
Wagner H. Immunostimulants and adaptogens from plants. In: Amason JT, Mata R, Romeo JT, editors. Phytochemistry of Medicinal Plants. New York: Plenum Press; 1995. p. 1-18.
Rajnarayana K, Reddy MS, Chaluvadi MR, Krishna DR. Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential. Indian J Pharmacol 2001;33:2-16.
Mutalik S, Paridhavi K, Mallikarjuna Rao C, Udupa N. Antipyretic and analgesic effect of Solanum melongena. Indian J Pharmacol 2003;35:312-5.
Moltz H. Fever: Causes and consequences. Neurosci Biobehav Rev 1993;17(3):237-69.
Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression. Proc Natl Acad Sci U S A 2002;99:13926â€‘31.
Srivastava S, Singh P, Jha KK, Mishra G, Srivastava S, Khosa RL. Antiinflammatory, analgesic and antipyretic activities of aerial parts of costus speciosus koen. Indian J Pharm Sci 2013;75(1):83-8.
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