• Bhushan S Bhoyar
  • Arun T Patil



Objective: The objective was to enhance the amount of active substance reaching the target tissue or exerting a local effect in the cul-de-sac, the
approach we use is the application of in-situ gelling systems or phase transition systems, which are instilled in a liquid form and shift to a gel or solid
phase in the cul-de-sac. The present study will focus on the development of formulation of ophthalmic gels. The polymer physicochemical properties
were studied for the improvement in gel characteristics.
Methods: The formulations were varied by the amount of the anionic and cationic polymer concentration. The 10 and 20-fold excess anionic polymer
were used. The 10 and 20-fold excess anionic polymer were used. Further cationic polymers were utilized to see any ternary interaction between
drug and polymers.
Results: From the present study it could be shown that most of the formulations were isotropic and could be clearly separated from the anisotropic
ones which were situated at the cationic side of the phase diagram only as well as at 10% polyvinyl alcohol. Furthermore, excess 20HA, 10PAA, and
20PAA as well as HCS (HCS/20PAA) contributes to improve drug release control.
Conclusion: The above formulation of were found to be quite stable and useful in the novel format of sol-gel transformations. Further, the physical
characteristics gels show better tolerability with anionic and cationic polymer.

Keywords: Cationic, Anionic, Poloxamer, Sol-gel.


Robinson JC. Ocular anatomy and physiology relevant to ocular drug delivery. In: Mitra AK, editor. Ophthalmic Drug Delivery Systems. New York: Marcel Dekker; 1993. p. 29-57.

Van Ooteghem MM. Factors influencing the retention of ophthalmic solutions on the eye surface. In: Saettone MF, Bucci M, Speiser P, editors. Ophthalmic Drug Delivery. Biopharmaceutical, Technological and Clinical Aspects, Fidia Research Series. Vol. 11., Padova: Livinia Press; 1987. p. 7-17.

Greaves JL, Wilson CG. Treatment of diseases of the eye with mucoadhesive delivery systems. Adv Drug Deliv Rev 1993;11(3):349‑83.

Ceulemans J, Ludwig A. Optimisation of carbomer viscous eye drops: An in-vitro experimental design approach using rheological techniques. Eur J Pharm Biopharm 2002;54(1):41-50.

Genta I, Conti B, Perugini P, Pavanetto F, Spadaro A, Puglisi G. Bioadhesive microspheres for ophthalmic administration of acyclovir. J Pharm Pharmacol 1997;49(8):737-42.

Suthanthiraraj SA, Kumar R, Paul BJ. FT-IR spectroscopic investigation of ionic interactions in PPG 4000: AgCF3SO3 polymer electrolyte. Spectrochim Acta A Mol Biomol Spectrosc 2009;71(5):2012-5.

Elibol O, Alçelik T, Yüksel N, Caglar Y. The influence of drop size of cyclopentolate, phenylephrine and tropicamide on pupil dilatation and systemic side effects in infants. Acta Ophthalmol Scand 1997;75(2):178‑80.

Paulsen FP, Föge M, Thale AB, Tillmann BN, Mentlein R. Animal model for the absorption of lipophilic substances from tear fluid by the epithelium of the nasolacrimal ducts. Invest Ophthalmol Vis Sci 2002;43(10):3137-43.9. Pandit JC, Nagyová B, Bron AJ, Tiffany JM. Physical properties of stimulated and unstimulated tears. Exp Eye Res 1999;68(2):247-53.

Shah A, Khan AM, Usman M, Qureshi R, Siddiq M, Shah SS. Thermodynamic characterization of dexamethasone sodium phosphate and its complex with DNA as studied by conductometric and spectroscopic techniques. J Chil Chem Soc 2009;54(2):134-7.



How to Cite

S Bhoyar, B., and A. T Patil. “FORMULATION AND EVALUATION OF OPHTHALMIC GEL BASED ON DRUG-POLYMER-POLYMER TERNARY INTERACTION”. Asian Journal of Pharmaceutical and Clinical Research, vol. 8, no. 3, May 2015, pp. 283-8,



Original Article(s)