• Prabavathy D
  • Valli Nachiyar C



Introduction; Endophytic fungi are mutualistic symbionts of plants producing bioactive secondary metabolites. Objective; The study was carried out to screen for phytochemicals and demonstrate the cyotoxicity, the ethyl acetate extracts of the plant Justicia beddomei and its endophytic fungi. Methods; Preliminary phytochemical screening was carried by standard procedures. The MTT assay of the extracts was carried out on A549 lung adenocarcinoma cells. Results; The endophytic Aspergillus had an IC 50 of 22.73µg/ml, while the plant extract had an IC 50 of   6.25µg/ml. The phytochemical screening of the extracts showed the presence of phenols, flavonoids, alkaloids, tannins and glycosides. Conclusion; The present study indicates the presence of anticancer compounds in the plant and its endophytic Aspergillus sp. The endophyte was shown to possess bioactivity three times than that of the host plant.


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How to Cite

D, P., and V. Nachiyar C. “CYTOTOXIC POTENTIAL AND PHYTOCHEMICAL ANALYSIS OF JUSTICIA BEDDOMEI AND ITS ENDOPHYTIC ASPERGILLUS SP”. Asian Journal of Pharmaceutical and Clinical Research, vol. 6, no. 9, Nov. 2013, pp. 159-61,