ANTI -ARTHRITIC POTENTIAL OF HELIANTHUS ANNUUS IN LABORATORY ANIMALS


Anupama Ashok Suralkar

Abstract


Objective: The present study was carried out to investigate the anti-arthritic potential of ethanolic extract of Helianthus annuus leaves (HA).
Methods: The effect of HA was evaluated for chronic inflammation by complete Freud’s adjuvant (CFA) induced arthritis in rats.
Results: The paw edema was measured along with biochemical, hematological, histopathological, radiographic parameters, and ulcerogenic potential.
In this study, pre-treatment with HA significantly decreased paw volume, arthritic index, spleen and thymus weight, ulcerogenic index; and inhibited
histopathological changes in joint cavity and inhibited destruction of the knee joints induced by CFA in radiographic examination. Treatment of
HA also restored significantly the hematological parameters such as hemoglobin level, total red blood cell, total white blood cell, and erythrocytsedimentation rate along with antioxidant parameters such as superoxide dismutase, catalase glutathione, and lipid peroxide. The serum marker of
arthritis such as C-reactive protein (CRP) and rheumatoid factor were also reduced in the HA-treated arthritic rats.
Conclusion: The results of the present study demonstrate the anti-arthritic potential of HA leaves in the anti-arthritic activity.
Keywords: Anti-arthritic, C-reactive protein, Complete Freud’s adjuvant, Helianthus annuus, Paw volume, Rheumatoid factor.


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About this article

Title

ANTI -ARTHRITIC POTENTIAL OF HELIANTHUS ANNUUS IN LABORATORY ANIMALS

Date

01-11-2015

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 8 Issue 6 (November - December) 2015 Page: 53-57

Print ISSN

0974-2441

Online ISSN

2455-3891

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141 Views | 229 Downloads

Authors & Affiliations

Anupama Ashok Suralkar
Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences & Research, Pimpri, Pune -411018, Maharashtra, India.
India


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