ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFCETS OF THE ETHANOLIC EXTRACT OF ALOCASIA INDICA RHIZOMES IN HIGH FAT DIET/STREPTOZOTOCIN AND STREPTOZOTOCIN/NICOTINAMIDE-INDUCED TYPE 2 DIABETIC RATS

  • Talha Jawaid Department of Pharmacology, Hygia Institute of Pharmaceutical Education and Research, Ghaila Road, Lucknow, Uttar Pradesh - 226 020, IndiaARGAL
  • Saumya Argal Department of Pharmacology, Hygia Institute of Pharmaceutical Education and Research, Ghaila Road, Lucknow, Uttar Pradesh - 226 020, India
  • Mehnaz Kamal Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow, Uttar Pradesh - 226 026, India

Abstract

Objective: The investigate the antidiabetic and antihyperlipidemic effect of ethanolic extract of Alocasia indica (EEAI) rhizomes in high-fat
diet/streptozotocin (HFD/STZ) and STZ/nicotinamide-induced Type 2 diabetic rats.
Methods: Diabetes was induced in male Wistar rats by the administration of a HFD for 15 days/STZ (35 mg/kg b.w., i.p.) and STZ (60 mg/kg b.w.,
i.p.)/nicotinamide (110 mg/kg b.w., i.p.). EEAI (100 and 200 mg/kg b.w., p.o.) was administered to diabetic rats for 28 days in HFD/STZ-induced
Type 2 diabetic rats and for 15 days in STZ/nicotinamide-induced Type 2 diabetic rats. The effect of EEAI on blood glucose and body weight was
studied in Type 2 diabetic rats. All these effects were compared with glibenclamide (5 mg/kg b.w., p.o.) as a reference antidiabetic drug.
Results: The administration of the EEAI (100 and 200 mg/kg b.w., p.o.) resulted in a significant decrease in blood glucose level and significant increase
in body weight in the HFD/STZ and STZ/nicotinamide-induced Type 2 diabetic rats. Further EEAI showed antihyperlipidemic activity as evidenced
by significant decrease in serum total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), very LDL-C levels coupled together with
elevation of high-density lipoprotein cholesterol level in diabetic rats in the HFD/STZ and STZ/nicotinamide-induced Type 2 diabetic rats.
Conclusion: The results suggest that the EEAI rhizomes possess a promising effect on the HFD/STZ and STZ/nicotinamide-induced Type 2 diabetes.
Keywords: Antidiabetic, Antihyperlipidemic, Alocasia indica, High-fat diet, Streptozotocin, Nicotinamide.

Author Biographies

Talha Jawaid, Department of Pharmacology, Hygia Institute of Pharmaceutical Education and Research, Ghaila Road, Lucknow, Uttar Pradesh - 226 020, IndiaARGAL

Department of Pharmacology, Hygia Institute of Pharmaceutical Education and Research, Ghaila Road, Lucknow, Uttar Pradesh - 226 020, India

Saumya Argal, Department of Pharmacology, Hygia Institute of Pharmaceutical Education and Research, Ghaila Road, Lucknow, Uttar Pradesh - 226 020, India

Department of Pharmacology, Hygia Institute of Pharmaceutical Education and Research, Ghaila Road, Lucknow, Uttar Pradesh - 226 020,  India



Mehnaz Kamal, Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow, Uttar Pradesh - 226 026, India

Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow, Uttar Pradesh - 226 026, India

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How to Cite
Jawaid, T., S. Argal, and M. Kamal. “ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFCETS OF THE ETHANOLIC EXTRACT OF ALOCASIA INDICA RHIZOMES IN HIGH FAT DIET/STREPTOZOTOCIN AND STREPTOZOTOCIN/NICOTINAMIDE-INDUCED TYPE 2 DIABETIC RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 6, Nov. 2015, pp. 58-62, https://innovareacademics.in/journals/index.php/ajpcr/article/view/7084.
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