EVALUATION OF ANTHELMINTIC ACTIVITY OF PRUNUS PERSICA (L.)
Objective: Prunus persica leaves are used as anthelmintic, insecticidal, sedative, diuretic, demulcent, expectorant and vermicidal ethnopharmacologically. Objective of present study was evaluation of anthelmintic activity of different extracts of Prunus persica leaves.
Methods: Pheretima posthuma (annelids) and Ascaridia galli (nematods) were used to perform experiments for anthelmintic activity. Piperazine citrate was used as standard. Time required for paralysis and death (lethal time) of worms were noted for each sample of P. persica extracts and standard.
Results: The results demonstrated that treatment withÂ Prunus persicaÂ significantly (P<0.05-P<0.01) with dose-dependently paralyzed and killed the both A. galli and earthworms. Ethanol and ethyl acetate extracts have showed comparable anthelmintic activity at the highest concentration (60 mg/ml) to the well known anthelmintic agent Piperazine citrate against A. galli.
Conclusion: The ethanolic & ethyl acetate extracts exhibited maximum potency i.e. shortest paralysis and lethal times. The potency was not more than the reference drug, piperazine citrate but comparable to it at 60 mg/ml concentrations in both test worms.
Keywords: Prunus. Persica, Anthelmintic activity, Pheretima posthuma, Ascaridia galli.
ed. Mumbai: Popular
Prakashan; 1996. p. 1236.
2. Kirtikar KR, Basu BD. Indian Medicinal Plant. 2
Oriental enterprises; 2001. p. 1533.
3. Deb L, Gupta R, Dutta AS, Yadav A, Bhowmik D, Kumar KP.
Evaluation of antioxidant activity of Prunus persica L. aqueous extract.
Pharm Sin 2010;1(3):157-64.
4. Shin TY, Park SB, Yoo JS, Kim IK, Lee HS, Kwon TK, et al. Antiallergic
NF-kappaB. Food Chem Toxicol
5. Suh SJ, Koo BS, Jin UH, Hwang MJ, Lee IS, Kim CH. Pharmacological
characterization of orally active cholinesterase inhibitory activity of
Prunus persica L. Batsch in rats. J Mol Neurosci. 2006;29(2):101-7.
6. Park SW, Survay NS, Ko EY, Upadhyay CP, Mi1 J. Hypoglycemic
effects of fruits and vegetables in hyperglycemic rats for prevention of
Type-2 Diabetes. Korean J Hortic Sci Technol 2010;28(5):1-7.
7. Kim YK, Koo BS, Gong DJ, Lee YC, Ko JH, Kim CH. Comparative
effect of Prunus persica L. BATSCH-water extract and tacrine
(9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration
of extracellular acetylcholine in the rat hippocampus. J Ethnopharmacol
8. Thorn GW, Adams RD, Brundwald E, Isselbacher KJ, Petersdorf RG.
Harrisonâ€™s Principles of Internal Medicine. New York: McGraw Hill
Co.; 1977. p. 1088.
9. Vigar Z. Atlas of Medical Parasitology. 2
ed. Singapore: P. G.
Publishing House; 1984. p. 216.
10. Vidyarthi RD. A Text Book of Zoology. New Delhi: S. Chand & Co.;
1967. p. 329-70.
11. Chatterjee KD. Parasitology, Protozoology and Helminthology.
Calcutta: Guha Ray Sree Saraswati Press Ltd.; 1967. p. 168-9.
12. Permin A, Bisgaard M, Frandsen F, Pearman M, Kold J, Nansen P.
Prevalence of gastrointestinal helminths in different poultry production
systems. Br Poult Sci 1999;40(4):439-43.
13. Ghosh T, Maity TK, Bose A, Dash GK. Anthelmintic activity of
Bracopa monnieri. Indian J Nat Prod 2005;21(2):16-9.
14. Lalchhandama K. Nematocidal effects of piperazine and the extract of
Acacia oxyphylla stem bark on the poultry nematode, Ascaridia galli.
15. Singh K, Nagaich S. Anthelmintic efficacy of the alcoholic extract of
Ocimum sanctum against common poultry worms Ascaridia galli and
Heterakis gallinae. J Parasit Dis 2002;26:42-5.
16. Singh K, Nagaich S. Efficacy of aqueous seed extract of Carica papaya
against common poultry worms Ascaridia galli and Heterakis gallinae.
J Parasit Dis 1999;23:113-6.
17. Kaushik RK, Katiyar JC, Sen AB. Studies on the mode of action of
anthelmintics with Ascaridia galli as the test parasite. Indian J Med Res
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