• Faten Mohammed Zahran
  • Ayman Salah El-deen Al-hussaini
  • Mohammed El-sayed El-shehabi


Objective: This study was performed to investigate the antidiabetic effect of caffeic acid and 18 β -glycyrrhetinic acid against diabetic rats.

Methods: In this experiment, the animals were divided into five groups. Group I: Normal rats. Group II: diabetic control rats.Group III: diabetic rats treated with 18β-glycyrrhetinic. Group IV: diabetic rats treated with caffeic acid. Group V: diabetic rats treated with 18β-glycyrrhetinic and caffeic acid. Fasting blood glucose, insulin, glutathione reductase (GR), glutathione peroxidase (GPx), total antioxidant (TAO), catalase , and superoxide dismutase (SOD) and malondialdehyde (MDA) were analyzed.

Results: Fasting blood glucose and MDA were significantly increased, whereas insuline, GR, GPx, TAO, catalase , SOD were decreased significantly in diabetic rats. Though the diabetic rats treated with caffeic acid and 18β-glycyrrhetinic acid individual exerts beneficial effects in all the biochemical parameters in diabetic rats. The combined treatment with caffeic acid and 18β-glycyrrhetinic acid normalized all the above-mentioned biochemical parameters in diabetic rats.

Conclusion: our findings demonstrated that 18β-glycyrrhetinic acid and  caffeic acid either used individually or in combination to diabetic rats have an antidiabetic effect and a good antioxidant property .From the results, the combined dose of 18β-glycyrrhetinic acid and caffeic acid to diabetic rats showed promising antidiabetic effect and antioxidant property compared to individual treatments.

Keywords: Diabetes, Caffeic acid, 18β-glycyrrhetinic acid, Streptozotocin, Antioxidant.


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How to Cite
Zahran, F. M., A. S. E.- deen Al-hussaini, and M. E.- sayed El-shehabi. “ANTIDIABETIC ACTIVITY OF CAFFEIC ACID AND 18Î’-GLYCYRRHETINIC ACID AND ITS RELATIONSHIP WITH THE ANTIOXIDANT PROPERTY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 5, Sept. 2015, pp. 229-35,
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