ABO BLOOD GROUPS IN CORRELATION WITH HYPERLIPIDEMIA, DIABETES MELLITUS TYPE II AND ESSENTIAL HYPERTENSION

  • Mohamed I Kotb El-sayed Faculty ofpharmacy, Helwan University,Cairo,EGYPT
  • Hatem K Amin Helwan university,Cairo, EGYPT

Abstract

Objectives: There are associations between ABO blood groups and systemic diseases. So we aim to explore any associations among ABO blood group
with hyperlipidemia; diabetes mellitus (DM) type II, and essential hypertension.
Methods: A total of 800 subjects were recruited. Patients groups were subdivided into hyperlipidemia group (n=100), DM type II group (n=160),
and hypertension group (n=166). Fasting blood sample was collected and plasma samples used for measuring of 2, 3-dinor-6-keto-prostaglandinF
1α
(PGF1α), 11-dehydro-thromboxane (TX) B
2
, insulin, triglycerides (TGs), total cholesterol (Tc), high-density lipoprotein cholesterol (HDL-C),
prothrombin time (PT), activated partial PT (aPPT), blood group type, random blood glucose level, and body mass index (BMI) were also determined.
Results: Blood Group A demonstrates a significant elevation in insulin, random blood sugar (RBS), Tc, TGs, and low-density lipoprotein (LDL)/HDL
ratio and shows a significant decrease in prostacyclin. Blood group B demonstrates a significant elevation in TXB
, Tc, TGs, and LDL/HDL ratio and
shows a significant decrease in PT. Blood group AB demonstrates a significant elevation in PT, and prostacyclin and shows a significant decrease in
insulin, RBS, Tc, TGs, and LDL/HDL. Blood group O demonstrates a significant elevation in PT, and prostacyclin and shows a significant decrease in
TXB2, Tc, TGs, and LDL/HDL ratio.
2
Conclusions: Blood group AB is protective against hyperlipidemia, diabetes, thrombosis, and hypertension, blood group O is protective against
cardiovascular diseases while blood group B followed by A are risk factors for hypertension and blood group A is a risk factor for diabetes. These
findings are establishing the ethnic-dependent correlation of ABO groups and studied diseases.
Keywords: Hyperlipidemia, DM type II, Hypertension, Thrombosis, ABO blood groups.

Author Biography

Mohamed I Kotb El-sayed, Faculty ofpharmacy, Helwan University,Cairo,EGYPT
Biochemistry and molecular biology depart.

References

1. Storry JR, Olsson ML. The ABO blood group system revisited: A
review and update. Immunohematology 2009;25(2):48-59.
2. Eastlund T. The histo-blood group ABO system and tissue
transplantation. Transfusion 1998;38(10):975-88.
3. Franchini M, Mannucci PM. ABO blood group and thrombotic vascular
disease. Thromb Haemost 2014;112(6):1103-9.
4. Gheisari R, Ghoreishian M, Movahedian B, Roozbehi A. The
association between blood groups and maxillofacial deformities. Indian
J Plast Surg 2008;41(2):138-40.
5. Adegnika AA, Luty AJ, Grobusch MP, Ramharter M, Yazdanbakhsh M,
Kremsner PG, et al. ABO blood group and the risk of placental malaria
in sub-Saharan Africa. Malar J 2011;10:101.
6. Ketch TR, Turner SJ, Sacrinty MT, Lingle KC, Applegate RJ,
Kutcher MA, et al. ABO blood types: Influence on infarct size, procedural
characteristics and prognosis. Thromb Res 2008;123(2):200-5.
7. Fang Y, Mohler ER rd, Hsieh E, Osman H, Hashemi SM,
Davies PF, et al. Hypercholesterolemia suppresses inwardly
rectifying K+ channels in aortic endothelium in vitro and in vivo.
Circ Res 2006;98(8):1064-71.
8. Nixon JV. Cholesterol management and the reduction of cardiovascular
risk. Prev Cardiol 2004;7(1):34-9.
9. Kaur M. Blood pressure trends and hypertension among rural and urban
Jat women of Haryana, India. Coll Antropol 2012;36(1):139-44.
10. O’Donnell J, Laffan MA. The relationship between ABO histoblood
group, factor
VIII
and von Willebrand
factor.
Transfus
Med
2001;11(4):343-51.
11. Ekoe JM, Zimmet P, Williams R. The Epidemiology of Diabetes
Mellitus: An International Perspective. Chichester: John Wiley; 2001.
12. Abdul Ghani W, Iqbal M, Awwab Khan O, Tahir M. Association of
diabetes mellitus with ABO and Rh blood groups. Ann Pak Inst Med
Sci 2012;8(2):134-6.
13. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA,
Izzo JL Jr, et al. The seventh report of the joint national committee on
prevention, detection, evaluation, and treatment of high blood pressure:
The JNC 7 report. JAMA 2003;289(19):2560-72.
14. American Diabetes Association. The diagnosis and classification of
diabetes mellitus. Diabetes Care 2004;27:s5-10.
15. Expert Panel on Detection, Evaluation, and Treatment of High Blood
Cholesterol in Adults. Executive summary of the third report of the
national cholesterol education program (NCEP) expert panel on
detection, evaluation, and treatment of high blood cholesterol in adults
(Adult Treatment Panel III). JAMA 2001;285(19):2486-97.
16. Trinder P. Estimation of triacylglycerol. Ann Clin Biochem
1969;6:24-7.
17. Zoppi F, Fellini D. Cholesterol estimation. Clin Chem 1976;22:690-1.
18. Wieland H, Siedel D. HDL cholesterol estimation. Artzl Lab
1981;27:141-54.
19. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the
concentration of low-density lipoprotein cholesterol in plasma,
without use of the preparative ultracentrifuge. Clin Chem
1972;18(6):499-502.
20. Dacie JV, Lewis SM. Tests for acute phase response. In: Practical
Hematology. 8th ed. New York: Churchill Livingstone; 1996. p. 559-63.
21. Sachdev B. Prevalence of hypertension and associated risk factors
among nomad tribe groups. Antrocom 2011;7(2):181-9.
22. Bhuiyan TR, Qadri F, Saha A, Svennerholm AM. Infection by
Helicobacter pylori in Bangladeshi children from birth to 2 years:
Relation to blood group, nutritional status, and seasonality. Pediatr
Infect Dis J 2009;28(2):79-85.
23. Menotti A, Kromhout D, Blackburn H, Jacobs D, Lanti M. Early and
late coronary deaths in the US Railroad study predicted by major
coronary risk factors. Eur J Cardiovasc Prev Rehabil 2004;11(5):382-8.
24. Schmitz G, Kaminski WE. ABCA2: A candidate regulator of neural
transmembrane lipid transport. Cell Mol Life Sci 2002;59(8):1285-95.
25. Wong FL, Kodama K, Sasaki H, Yamada M, Hamilton HB.
Longitudinal study of the association between ABO phenotype and
total serum cholesterol level in a Japanese cohort. Genet Epidemiol
1992;9(6):405-18.
26. Teupser D, Baber R, Ceglarek U, Scholz M, Illig T, Gieger C, et al.
Genetic regulation of serum phytosterol levels and risk of coronary
artery disease. Circulation 2010;3(4):331-9.
27. Gillum RF. Blood groups, serum cholesterol, serum uric acid,
blood pressure, and obesity in adolescents. J Natl Med Assoc
1991;83(8):682-8.
28. Stakisaitis D, Maksvytis A, Benetis R, Viikmaa M. Coronary
atherosclerosis and blood groups of ABO system in women (own data
and review). Medicina (Kaunas) 2002;38:230-5.
29. Napoli C, Pignalosa O, de Nigris F, Sica V. Childhood infection and
endothelial dysfunction: A potential link in atherosclerosis? Circulation
2005;111(13):1568-70.
30. Chandra T, Gupta A. Association and distribution of hypertension,
obesity and ABO Blood groups in blood donors. Iran J Ped Hematol
Oncol 2012;2(4):140-5.
31. Nishi K, Gupta NK, Sharma SC. Study on the incidence of hypertension
and migraine in ABO blood groups. ISCA J Biol Sci 2012;1(2):12-6.
32. Bezemer ID, Rosendaal FR. Predictive genetic variants for venous
thrombosis: What’s new? Semin Hematol 2007;44(2):85-92.
33. Larsen TB, Johnsen SP, Gislum M, Møller CA, Larsen H,
Sørensen HT. ABO blood groups and risk of venous thromboembolism
during pregnancy and the puerperium. A population-based, nested casecontrol
study.
J
Thromb
Haemost 2005;3(2):300-4.
34. Carpeggiani C, Coceani M, Landi P, Michelassi C, L’abbate A. ABO
blood group alleles: A risk factor for coronary artery disease. An
angiographic study. Atherosclerosis 2010;211(2):461-6.
35. Platt D, Mühlberg W, Kiehl L, Schmitt-Rüth R. ABO blood group
system, age, sex, risk factors and cardiac infarction. Arch Gerontol
Geriatr 1985;4(3):241-9.
36. Whincup PH, Cook DG, Phillips AN, Shaper AG. ABO blood group and
ischaemic heart disease in British men. BMJ 1990;300(6741):1679-82.
37. Tarján Z, Tonelli M, Duba J, Zorándi A. Correlation between ABO
and Rh blood groups, serum cholesterol and ischemic heart disease in
patients undergoing coronarography. Orv Hetil 1995;136(15):767-9.
38. Makoui RH. Relationship between blood groups and occurrence of
coronary artery Disease (CAD) in patients hospitalized in Vali-Asr
hospital of Zanjan. Life Sci J 2013;10(5):142-6.
39. Dentali F, Sironi AP, Ageno W, Bonfanti C, Crestani S, Frattini F,
et al. Relationship between ABO blood group and hemorrhage: A
systematic literature review and meta-analysis. Semin Thromb Hemost
2013;39(1):72-82.
40. Schulze MB, Kroke A, Saracci R, Boeing H. The effect of differences
in measurement procedure on the comparability of blood pressure
estimates in multi-centre studies. Blood Press Monit 2002;7(2):95-104.
41. Gonzales RJ, Ghaffari AA, Duckles SP, Krause DN. Testosterone
268
Asian J Pharm Clin Res, Vol 8, Issue 5, 2015, 262-269
El-Sayed and Amin
treatment increases thromboxane function in rat cerebral arteries. Am
J Physiol Heart Circ Physiol 2005;289(2):H578-85.
42. Wilson DP, Susnjar M, Kiss E, Sutherland C, Walsh MP. Thromboxane
A2-induced contraction of rat caudal arterial smooth muscle involves
activation of Ca2 entry and Ca2 sensitization: Rho-associated kinasemediated
phosphorylation
of
MYPT1 at Thr-855,
but not
Thr-697.

Biochem
J 2005;389:763-74.
43. Meade TW, Cooper JA, Stirling Y, Howarth DJ, Ruddock V, Miller GJ.
Factor VIII, ABO blood group and the incidence of ischaemic heart
disease. Br J Haematol 1994;88(3):601-7.
44. Skaik YA. ABO blood groups and myocardial infarction among
Palestinians. Ann Card Anaesth 2009;12(2):173-4.
45. Biswas J, Islam MA, Rudra S, Haque MA, Bhuiyan ZR, Husain M,
et al. Relationship between blood groups and coronary artery disease.
Mymensingh Med J 2008;17 2 Suppl: S22-7.
46. Koley S. The distribution of the ABO blood types in patients with
diabetes mellitus. Anthropologist 2008;10:129-32.
47. Qi L, Cornelis MC, Kraft P, Jensen M, van Dam RM, Sun Q,
et al. Genetic variants in ABO blood group region, plasma soluble
E-selectin levels and risk of type 2 diabetes. Hum Mol Genet
2010;19(9):1856-62.
48. Hanley WB. Hereditary aspects of duodenal ulceration: Serumpepsinogen
level
in
relation to
abo
blood
groups
and salivary
ABH

secretor
status. Br Med J 1964;1(5388):936-40.
49. Taggart RT, Mohandas TK, Shows TB, Bell GI. Variable numbers
of pepsinogen genes are located in the centromeric region of human
chromosome 11 and determine the high-frequency electrophoretic
polymorphism. Proc Natl Acad Sci U S A 1985;82(18):6240-4.
50. Andersen J, Lauritzen E. Blood groups and diabetes mellitus. Diabetes
1960;9:20-4.
51. McConnell RB, Pyke DA, Roberts JA. Blood groups in diabetes
mellitus. Br Med J 1956;1(4970):772-6.
52. Kamil M, Al-Jamal HA, Yusoff NM. Association of ABO blood groups
with diabetes mellitus. Libyan J Med 2010;5.
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How to Cite
Kotb El-sayed, M. I., and H. K. Amin. “ABO BLOOD GROUPS IN CORRELATION WITH HYPERLIPIDEMIA, DIABETES MELLITUS TYPE II AND ESSENTIAL HYPERTENSION”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 5, Sept. 2015, pp. 236-43, https://innovareacademics.in/journals/index.php/ajpcr/article/view/7520.
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