• Mohamed I Kotb El-sayed Faculty ofpharmacy, Helwan University,Cairo,EGYPT
  • Hatem K Amin Helwan university,Cairo, EGYPT


Objectives: There are associations between ABO blood groups and systemic diseases. So we aim to explore any associations among ABO blood group
with hyperlipidemia; diabetes mellitus (DM) type II, and essential hypertension.
Methods: A total of 800 subjects were recruited. Patients groups were subdivided into hyperlipidemia group (n=100), DM type II group (n=160),
and hypertension group (n=166). Fasting blood sample was collected and plasma samples used for measuring of 2, 3-dinor-6-keto-prostaglandinF
(PGF1α), 11-dehydro-thromboxane (TX) B
, insulin, triglycerides (TGs), total cholesterol (Tc), high-density lipoprotein cholesterol (HDL-C),
prothrombin time (PT), activated partial PT (aPPT), blood group type, random blood glucose level, and body mass index (BMI) were also determined.
Results: Blood Group A demonstrates a significant elevation in insulin, random blood sugar (RBS), Tc, TGs, and low-density lipoprotein (LDL)/HDL
ratio and shows a significant decrease in prostacyclin. Blood group B demonstrates a significant elevation in TXB
, Tc, TGs, and LDL/HDL ratio and
shows a significant decrease in PT. Blood group AB demonstrates a significant elevation in PT, and prostacyclin and shows a significant decrease in
insulin, RBS, Tc, TGs, and LDL/HDL. Blood group O demonstrates a significant elevation in PT, and prostacyclin and shows a significant decrease in
TXB2, Tc, TGs, and LDL/HDL ratio.
Conclusions: Blood group AB is protective against hyperlipidemia, diabetes, thrombosis, and hypertension, blood group O is protective against
cardiovascular diseases while blood group B followed by A are risk factors for hypertension and blood group A is a risk factor for diabetes. These
findings are establishing the ethnic-dependent correlation of ABO groups and studied diseases.
Keywords: Hyperlipidemia, DM type II, Hypertension, Thrombosis, ABO blood groups.

Author Biography

Mohamed I Kotb El-sayed, Faculty ofpharmacy, Helwan University,Cairo,EGYPT
Biochemistry and molecular biology depart.


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How to Cite
Kotb El-sayed, M. I., and H. K. Amin. “ABO BLOOD GROUPS IN CORRELATION WITH HYPERLIPIDEMIA, DIABETES MELLITUS TYPE II AND ESSENTIAL HYPERTENSION”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 5, Sept. 2015, pp. 236-43, https://innovareacademics.in/journals/index.php/ajpcr/article/view/7520.
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