ABO BLOOD GROUPS IN CORRELATION WITH HYPERLIPIDEMIA, DIABETES MELLITUS TYPE II AND ESSENTIAL HYPERTENSION
Abstract
Objectives: There are associations between ABO blood groups and systemic diseases. So we aim to explore any associations among ABO blood group
with hyperlipidemia; diabetes mellitus (DM) type II, and essential hypertension.
Methods: A total of 800 subjects were recruited. Patients groups were subdivided into hyperlipidemia group (n=100), DM type II group (n=160),
and hypertension group (n=166). Fasting blood sample was collected and plasma samples used for measuring of 2, 3-dinor-6-keto-prostaglandinF
1α
(PGF1α), 11-dehydro-thromboxane (TX) B
2
, insulin, triglycerides (TGs), total cholesterol (Tc), high-density lipoprotein cholesterol (HDL-C),
prothrombin time (PT), activated partial PT (aPPT), blood group type, random blood glucose level, and body mass index (BMI) were also determined.
Results: Blood Group A demonstrates a significant elevation in insulin, random blood sugar (RBS), Tc, TGs, and low-density lipoprotein (LDL)/HDL
ratio and shows a significant decrease in prostacyclin. Blood group B demonstrates a significant elevation in TXB
, Tc, TGs, and LDL/HDL ratio and
shows a significant decrease in PT. Blood group AB demonstrates a significant elevation in PT, and prostacyclin and shows a significant decrease in
insulin, RBS, Tc, TGs, and LDL/HDL. Blood group O demonstrates a significant elevation in PT, and prostacyclin and shows a significant decrease in
TXB2, Tc, TGs, and LDL/HDL ratio.
2
Conclusions: Blood group AB is protective against hyperlipidemia, diabetes, thrombosis, and hypertension, blood group O is protective against
cardiovascular diseases while blood group B followed by A are risk factors for hypertension and blood group A is a risk factor for diabetes. These
findings are establishing the ethnic-dependent correlation of ABO groups and studied diseases.
Keywords: Hyperlipidemia, DM type II, Hypertension, Thrombosis, ABO blood groups.
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