PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL FOR PLANT-BASED ANTI-OXIDANT DRUGS

Authors

  • Baskar Viswanathan DEPARTMENT OF CHEMISTRY, THE NEW COLLEGE, New No. 147, Old No. 87, Peter’s Road, Chennai, Tamil Nadu 600014 http://orcid.org/0000-0002-4004-2550
  • Shabeer Tks DEPARTMENT OF CHEMISTRY, THE NEW COLLEGE, New No. 147, Old No. 87, Peter’s Road, Chennai, Tamil Nadu 600014
  • Afiya Razia Chida DEPARTMENT OF BIOINFORMATICS, SRM UNIVERSITY, KATTANGLATHUR, TAMIL NADU PLOT NO 21, DOOR NO: 5/19, GIRI NAGAR, RAMAPURAM, CHENNAI-600089 8939465857, 044-22490591
  • Deepa Mary Stanly BIOLIM BIOSOLUTIONS PRIVATE LIMITED, KONNUR HIGH ROAD, AYANAVARAM, CHENNAI-600023

DOI:

https://doi.org/10.22159/ajpcr.2016.v9s3.7894

Abstract

ABSTRACT
Objective: A pharmacokinetic study is a cumbersome process in clinical research. It is very important in target validation and in shifting a lead
compound into a drug. Our major objective was to reveal the most important physiochemical characters of the plant-based anti-oxidants in align with
human physiology. The in silico studies can preferably be the best solution to identify the physiologically-based pharmacokinetic (PBPK) behavior of
the anti-oxidants.
Methods: Anti-oxidants are found in many foods including fruits and vegetables. Few of the important anti-oxidants, i.e. around 10 plant-based antioxidant
compounds were taken for this research. These compounds were evaluated based on their pharmacokinetic parameters. The properties such
as Lipinski's rule of 5, absorption, distribution, metabolism, excretion, and toxicity (ADMET) of the compounds were screened thoroughly with the
help of tools such as molinspiration and gastroplus.
Results: The physiological studies of these compounds had shown different compartmental absorptions of the compound in the human gastrointestinal
tract. Certain compounds were found to pass the physiological barriers and had the ability to become a drug. The compounds were filtered using the
risk and toxicity factors. These risk factors caused the compounds to fail in the process of becoming a drug.
Conclusion: The compounds which passed the PBPK studies were eligible to become a drug. Of the 10 compounds investigated, eugenol, gingerol,
zingerone, and geraniol were found to have higher fraction of absorption to become a drug. Out of these compounds, the compounds gingerol and
eugenol have shown the best factor of absorption, and hence, have a better probability of becoming a drug.
Keywords: Anti-oxidants, Lipinski, Absorption, Distribution, Metabolism, Excretion and toxicity, Physiological properties, GastroPlus, In silico.

Author Biographies

Baskar Viswanathan, DEPARTMENT OF CHEMISTRY, THE NEW COLLEGE, New No. 147, Old No. 87, Peter’s Road, Chennai, Tamil Nadu 600014

Research expertise are in the area of nano drug delivery systems, pharmacokinetics and other social value creating project such as diabetes management. 

I'm part of various research group both in institution and industry and served as principal investigator. 

Shabeer Tks, DEPARTMENT OF CHEMISTRY, THE NEW COLLEGE, New No. 147, Old No. 87, Peter’s Road, Chennai, Tamil Nadu 600014

My thrust area of research is polymer chemistry and produced novel polymers which has several application in clinical health sector.

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Published

2016-12-01

How to Cite

Viswanathan, B., S. Tks, A. R. Chida, and D. M. Stanly. “PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL FOR PLANT-BASED ANTI-OXIDANT DRUGS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 9, Dec. 2016, pp. 223-9, doi:10.22159/ajpcr.2016.v9s3.7894.

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