DESIGN AND EVALUATION OF NOVEL TOPICAL GEL OF TINOSPORA CORDIFOLIA AS ANTIMICROBIAL AGENT


R. Supriya Hyam, Abhishek X D Dorle, Kumar S. Swami, Sujit K. Nagare

Abstract


Objective: The present study deals with topical formulations of a bioactive extract of Tinospora cordifolia and its evaluation.
Methods: Dried, powdered stem was extracted with chloroform using ultra-sonication method for 3 hrs. Topical formulations like gels containing
chloroform extract were formulated using various gelling agents. These gels were evaluated for physicochemical parameters, viscosity, spreadaibility,
and antimicrobial activity.
Results: A topical gel was successfully formulated containing bioactive chloroform extract of T. cordifolia. The gel was very effective as antimicrobial
formulations.
Conclusion: These kinds of formulations can be very promising wound healing medicines with ease of use and no side effects.
Keywords: Topical gel, Tinospora Cordifolia, Anitmictobial


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References


Yamauchi A. Gels: Introduction. In: Osade Y, Kajiwara K, editors. Gels

Handbook. Vol. 1. San Diego: The Fundamentals, Academic Press;

p. 4-12.

Rana V, Thakur K, Sood R, Sharma V, Sharma TR. Genetic diversity

analysis of Tinospora cordifolia germplasm collected from northwestern

Himalayan region of India. J Genet 2012;91(1):99-103.

Parthipan M, Aravindhan V, Rajendran A. Medico-botanical study of

Yercaud hills in the Eastern Ghats of Tamil Nadu, India. Anc Sci Life

;30(4):104-9.

Upadhyay AK, Kumar K, Kumar A, Mishra HS. Tinospora cordifolia

(Willd.) Hook. f. and Thoms. (Guduchi)-validation of the Ayurvedic

pharmacology through experimental and clinical studies. Int J Ayurveda

Res 2010;1:112-21.

Sharma U, Bala M, Kumar N, Singh B, Munshi RK, Bhalerao S.

Immunomodulatory active compounds from Tinospora cordifolia.

J Ethnopharmacol 2012;141(3):918-26.

Patel MB, Mishra S. Hypoglycemic activity of alkaloidal fraction of

Tinospora cordifolia. Phytomedicine 2011;18(12):1045-52.

Umachigi SP, Jayaveera K, Ashok Kumar CK. Evaluation of wound

healing potential of poly herbal formulation. Pharmacol Online

;3:505-12.

Panda P, Ghosh A. Formulation and Evaluation of topical dosage form

of Eupatorium odoratum Linn. and their wound healing activity. Int J

Pharm Biol Sci 2010;2:1-10.

Mohamed MI. Optimization of chlorphenesin emulgel formulation.

AAPS J 2004;6(3):e26.

El Gendy AM, Jun HW, Kassem AA. In vitro release studies of

flurbiprofen from different topical formulations. Drug Dev Ind Pharm

;28(7):823-31.

Shivhar UD, Jain KB, Mathur VB. Formulation development and

evaluation of diclofenac sodium gel using water soluble Poly acrylamide

polymer. Dig J Nanomater Biostruct 2009;4:285-90.

Gupta GD, Gound RS. Release rate of Nimesulide from different

gellants. Indian J Pharm Sci 1999;61:229-34.

Modarresi Chahardehi A, Ibrahim D, Fariza Sulaiman S. Antioxidant,

antimicrobial activity and toxicity test of Pilea microphylla. Int J

Microbiol 2010;2010:826830.

Ofori-Kwakye K, Kwapong AA, Adu F. Antimicrobial activity

of extracts and topical products of the stem bark of Spathodea

campanulata for wound healing. Afr J Tradit Complement Altern Med

;6(2):168-74.

Olila D, Olwa-Odyek, Opuda-Asibo J. Antibacterial and antifungal

activities of extracts of Zanthoxylum chalybeum and Warburgia

ugandensis, Ugandan medicinal plants. Afr Health Sci 2001;1(2):66-72.

El Maghraby GM, Barry BW, Williams AC. Liposomes and

skin: From drug delivery to model membranes. Eur J Pharm Sci

;34(4-5):203-22.

Bhalodia NR, Shukla VJ. Antibacterial and antifungal activities from

leaf extracts of Cassia 415847 l.: An ethnomedicinal plant. J Adv

Pharm Technol Res 2011;2(2):104-9.




About this article

Title

DESIGN AND EVALUATION OF NOVEL TOPICAL GEL OF TINOSPORA CORDIFOLIA AS ANTIMICROBIAL AGENT

Date

01-11-2015

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 8 Issue 6 (November - December) 2015 Page: 237-239

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

R. Supriya Hyam

Abhishek X D Dorle

Kumar S. Swami

Sujit K. Nagare


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