• R. Supriya Hyam
  • Abhishek X D Dorle
  • Kumar S. Swami
  • Sujit K. Nagare


Objective: The present study deals with topical formulations of a bioactive extract of Tinospora cordifolia and its evaluation.
Methods: Dried, powdered stem was extracted with chloroform using ultra-sonication method for 3 hrs. Topical formulations like gels containing
chloroform extract were formulated using various gelling agents. These gels were evaluated for physicochemical parameters, viscosity, spreadaibility,
and antimicrobial activity.
Results: A topical gel was successfully formulated containing bioactive chloroform extract of T. cordifolia. The gel was very effective as antimicrobial
Conclusion: These kinds of formulations can be very promising wound healing medicines with ease of use and no side effects.
Keywords: Topical gel, Tinospora Cordifolia, Anitmictobial


1. Yamauchi A. Gels: Introduction. In: Osade Y, Kajiwara K, editors. Gels
Handbook. Vol. 1. San Diego: The Fundamentals, Academic Press;
2001. p. 4-12.
2. Rana V, Thakur K, Sood R, Sharma V, Sharma TR. Genetic diversity
analysis of Tinospora cordifolia germplasm collected from northwestern
Himalayan region of India. J Genet 2012;91(1):99-103.
3. Parthipan M, Aravindhan V, Rajendran A. Medico-botanical study of
Yercaud hills in the Eastern Ghats of Tamil Nadu, India. Anc Sci Life
4. Upadhyay AK, Kumar K, Kumar A, Mishra HS. Tinospora cordifolia
(Willd.) Hook. f. and Thoms. (Guduchi)-validation of the Ayurvedic
pharmacology through experimental and clinical studies. Int J Ayurveda
Res 2010;1:112-21.
5. Sharma U, Bala M, Kumar N, Singh B, Munshi RK, Bhalerao S.
Immunomodulatory active compounds from Tinospora cordifolia.
J Ethnopharmacol 2012;141(3):918-26.
6. Patel MB, Mishra S. Hypoglycemic activity of alkaloidal fraction of
Tinospora cordifolia. Phytomedicine 2011;18(12):1045-52.
7. Umachigi SP, Jayaveera K, Ashok Kumar CK. Evaluation of wound
healing potential of poly herbal formulation. Pharmacol Online
8. Panda P, Ghosh A. Formulation and Evaluation of topical dosage form
of Eupatorium odoratum Linn. and their wound healing activity. Int J
Pharm Biol Sci 2010;2:1-10.
9. Mohamed MI. Optimization of chlorphenesin emulgel formulation.
AAPS J 2004;6(3):e26.
10. El Gendy AM, Jun HW, Kassem AA. In vitro release studies of
flurbiprofen from different topical formulations. Drug Dev Ind Pharm
11. Shivhar UD, Jain KB, Mathur VB. Formulation development and
evaluation of diclofenac sodium gel using water soluble Poly acrylamide
polymer. Dig J Nanomater Biostruct 2009;4:285-90.
12. Gupta GD, Gound RS. Release rate of Nimesulide from different
gellants. Indian J Pharm Sci 1999;61:229-34.
13. Modarresi Chahardehi A, Ibrahim D, Fariza Sulaiman S. Antioxidant,
antimicrobial activity and toxicity test of Pilea microphylla. Int J
Microbiol 2010;2010:826830.
14. Ofori-Kwakye K, Kwapong AA, Adu F. Antimicrobial activity
of extracts and topical products of the stem bark of Spathodea
campanulata for wound healing. Afr J Tradit Complement Altern Med
15. Olila D, Olwa-Odyek, Opuda-Asibo J. Antibacterial and antifungal
activities of extracts of Zanthoxylum chalybeum and Warburgia
ugandensis, Ugandan medicinal plants. Afr Health Sci 2001;1(2):66-72.
16. El Maghraby GM, Barry BW, Williams AC. Liposomes and
skin: From drug delivery to model membranes. Eur J Pharm Sci
17. Bhalodia NR, Shukla VJ. Antibacterial and antifungal activities from
leaf extracts of Cassia 415847 l.: An ethnomedicinal plant. J Adv
Pharm Technol Res 2011;2(2):104-9.
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How to Cite
Hyam, R., A. X. Dorle, K. S. Swami, and S. K. Nagare. “DESIGN AND EVALUATION OF NOVEL TOPICAL GEL OF TINOSPORA CORDIFOLIA AS ANTIMICROBIAL AGENT”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 6, Nov. 2015, pp. 237-9,
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