PREVALENCE OF ANTI-HCV, HBSAG, HIV AMONG MULTI-TRANSFUSED THALASSEMIC INDIVIDUALS AND THEIR SOCIO-ECONOMIC BACKGROUND IN EASTERN INDIA

  • Aritra Biswas ICMR VIRUS UNIT, KOLKATA
  • Kahini Sarkar ICMR VIRUS UNIT, KOLKATA
  • Rushna Firdaus ICMR VIRUS UNIT, KOLKATA
  • Kallol Saha ICMR VIRUS UNIT, KOLKATA
  • Debanjali Gupta ICMR VIRUS UNIT, KOLKATA
  • Monika Ghosh ICMR VIRUS UNIT, KOLKATA
  • Prosanto Chowdhury Peerless Hospital & B. K. Roy Research Centre, Kolkata – 700094,
  • Debmalya Bhattacharyya Calcutta Medical College, 88, College Street; Kolkata-700073
  • Maitreyee Bhattacharya Calcutta Medical College, 88, College Street; Kolkata-700073
  • Provash Chandra Sadhukhan ICMR VIRUS UNIT, KOLKATA

Abstract

Objective: The objective was to study the serological prevalence of post-transfusion transmitted infections such as hepatitis C virus (HCV), hepatitis
B virus (HBV), and HIV among multi-transfused thalassemic individuals of the Eastern India and the socio and financial difficulties faced by them.
Methods: The study was carried out from January 2012 until December 2014 involving 1711 thalassemic major individuals. Blood serum was
collected from each patient to perform ELISA for the detection of HBV and HCV seroprevalence. HIV seropositivity along with their hematological and
liver function parameters were obtained from the transfusion centers and the host institutions. Other socio-economic conditions were obtained by
predesigned proforma of the questionnaire.
Results: 67.9% males and 32.1% females were present in our study population of which 75% were from rural area. The mean hemoglobin was found
to be lower, whereas mean ferritin, bilirubin, and liver enzymes were much higher than the normal range. Only a handful of 19.76% of the fathers of
thalassemic individuals had secondary education. 263 families (15.37%) were familiar with the chances of transfusion-transmitted infections (TTIs).
The dominant TTI found within the population was HCV with 18.70% prevalence followed by HIV (3.74%) and HBV (3.33%). 82.93% of the affected
families suffered poverty with a meager monthly income within Rs. 5000 fighting against high costs of transfusion and related treatments.
Conclusion: Our study reflects the different socio-economic and psychological burdens faced by the thalassemia patients and their families. The high
rate of TTIs highlights the need for stringent screening of blood or blood products before administration.
Keywords: Thalassemia, Socio-economic, Transfusion-transmitted infections, Hepatitis C virus, Hepatitis B virus, HIV.

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How to Cite
Biswas, A., K. Sarkar, R. Firdaus, K. Saha, D. Gupta, M. Ghosh, P. Chowdhury, D. Bhattacharyya, M. Bhattacharya, and P. C. Sadhukhan. “PREVALENCE OF ANTI-HCV, HBSAG, HIV AMONG MULTI-TRANSFUSED THALASSEMIC INDIVIDUALS AND THEIR SOCIO-ECONOMIC BACKGROUND IN EASTERN INDIA”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 1, Jan. 2016, pp. 314-8, https://innovareacademics.in/journals/index.php/ajpcr/article/view/9134.
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