@article{Kartolo_Tjandrawinata_Suparman_Susanto_Suparman_2016, title={CLINICAL EXPERIENCE WITH DLBS3233, A COMBINATION OF CINNAMOMMUM BURMANNII AND LAGERSTROEMIA SPECIOSA, FOR POLYCYSTIC OVARY SYNDROME TREATMENT}, volume={9}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/10245}, abstractNote={<p>ABSTRACT<br />Objective: DLBS3233, a new insulin sensitizing agent for Type 2 diabetes, is a combination-bioactive-fraction derived from two herbs, i.e., Lagerstroemia<br />speciosa and Cinnamomum burmannii. Since insulin resistance plays a central pathogenic role in polycystic ovary syndrome (PCOS), DLBS3233 has the<br />potential to benefit women with such a condition, in whom menstrual irregularity, chronic anovulation or infertility are manifested. This clinical study<br />was performed to evaluate the clinical efficacy of DLBS3233 as a single pharmacological therapy in improving follicle maturity in women with PCOS<br />measured by a transvaginal ultrasonography (USG).<br />Methods: The open study enrolled 14 PCOS subjects from the Obstetrics and Gynecology Department of Sam Ratulangi University/Prof. Dr. Kandou<br />Hospital, satellite hospitals, and private practices. Patients were measured for the dominant follicle diameter using transvaginal USG. Subjects were<br />given DLBSS3233 capsule at a dose of 1 capsule at 100 mg once daily for 30 days of the treatment. At the end of the study, patients’ follicle diameters<br />were re-assessed. The difference in follicle diameters was compared within the group (within-subject) by paired t-test, with a significance level (α)<br />of 0.05.<br />Results: Among 14 PCOS enrolled subjects, 57.2% aged between 26 and 30 years old. There were similar proportions of subjects with normal body<br />mass index (42.8%) and overweight(42.8%). Before treatment (at baseline), the mean follicle diameter was 4.094±1.016 mm. After 30 days of<br />treatment, it increased significantly to 8.594±1.647 mm (p<0.001 versus baseline). There were 10 subjects (71.4%) showed follicles with size ranging<br />between 5 and 10 mm, while the remaining 4 subjects (28.6%) had them bigger than 10 mm.<br />Conclusion: Through this study, DLBS3233 at the dose of 100 mg once daily for 30 days showed a potential benefit for PCOS patients, particularly in<br />improving follicle maturity expressed as an increased follicular diameter.<br />Keywords: DLBS3233, Cinnamomum burmannii, Follicle diameter, Lagerstroemia speciosa, Polycystic ovary syndrome.</p>}, number={2}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={Kartolo, Darsono and Tjandrawinata, Raymond R. and Suparman, Eddy and Susanto, Liana W. and Suparman, Erna}, year={2016}, month={Mar.}, pages={40–43} }