@article{H. Nour_Khan_Sulaiman_Batool_H. Nour_Mumtaz Khan_Kormin_2014, title={IN VITRO ANTI-ACETYL CHOLINESTERASE AND ANTIOXIDANT ACTIVITY OF SELECTED MALAYSIAN PLANTS}, volume={7}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/1169}, abstractNote={<p>Objective: The aim of this study is to discover and identify the potential plant extracts that could be vital against Alzheimer’s disease (AD). It is a neurodegenerative disease affecting the brain. The most promising target for the symptomatic treatment and slowing of AD progression is cholinesterase inhibitors from plants.</p><p> </p><p>Methods: To evaluate the antioxidant and anti-acetylcholinesterase (AChEI) activities leaves and roots were macerated and refluxed with ethanol extracts, from four medicinal plants, namely; <em>C.asiatica, M.pudica, C.pumila</em>,<em> </em>and <em>L.camara. </em>DPPH and β-carotene assays were used to determine antioxidant activity; whereas Ellman’s colorimetric method was adopted to quantify AChEI activity.</p><p> </p><p>Results: The refluxed ethanol extract of <em>M.pudica </em>leaves exhibited the highest AChEI activity (IC<sub>50</sub> = 0.047 mg/ml) and high antioxidant activity (β-carotene; IC<sub>50</sub> = 0.14 mg/ml and DPPH; IC<sub>50</sub> = 0.012 mg/ml).</p><p> </p><p>Conclusion: Results reveal that all plant extracts studied possess anti-oxidant properties. Most potent extracts could be a lead to novel antioxidants and acetyl cholinesterase inhibitors, for the treatment of AD.<strong></strong></p><p> </p><strong><em>Keywords</em></strong>; Alzheimer’s disease (AD); Acetylcholinesterase activity; Antioxidant activity; β-carotene; DPPH; Medicinal plants.}, number={3}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={H. Nour, Azhari and Khan, Muhammad and Sulaiman, Ahmad Ziad and Batool, Tahira and H. Nour, ABDURAHMAN and Mumtaz Khan, Muhammad and Kormin, Faridah}, year={2014}, month={Jul.}, pages={93–97} }