@article{i_VIJAYALAKSHMI K_2016, title={PRELIMINARY PHYTOCHEMICAL SCREENING AND IN-VITRO FREE RADICAL SCAVENGING ACTIVITY OF ROOT EXTRACTS OF GLYCYRRHIZA GLABRA L}, volume={9}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/13675}, DOI={10.22159/ajpcr.2016.v9i6.13675}, abstractNote={<p><strong>ABSTRACT:</strong></p><p><strong>     </strong>Obesity is an international health problem caused by various environmental and genetic factors. Herbal supplements have proved to be active against obesity. <em>Glycyrrhiza glabra </em>belongs to the family of <em>Fabaceae. Glycyrrhiza glabra </em>was used traditionally to treat various diseases. Hence the current study was planned to investigate the phytochemicals and antioxidants present in <em>Glycyrrhiza glabra</em>. <strong>Materials and Methods: </strong>The preliminary qualitative, quantitative phytochemicals and antioxidants were investigated from the root extracts of <em>Glycyrrhiza glabra</em>. <strong>Results: </strong>The preliminary qualitative analysis of various extracts of <em>Glycyrrhiza glabra</em> showed the presence of Phenols, Flavonoids, Tannins, Saponins and Quinones. Quantitative analysis of <em>Glycyrrhiza glabra </em>showed elevated amounts of phenols, flavonoids and tannins in ethanolic extracts. The Aqueous, ethanol, hydro alcoholic extracts of <em>Glycyrrhiza glabra</em> showed 211±2.64, 281.66±1.57, 263±14.2 mg of phenols, 152.66±3.05, 187.33±1.52, 183.33±3.05 mg of flavonoids, 21.33±0.57, 41±3.46, 34.3±1.15 mg of Tannins, 42.33±2.05, 63.33±1.52, 36.33±1.57 mg of terpenoids. The antioxidant properties of the ethanolic extract of <em>Glycyrrhiza glabra </em>were evaluated with the 2,2-diphenyl-1-picryl hydrazyl (DPPH), Nitric Oxide radical (NO), Superoxide radical (SO), Hydrogen peroxide radical (H<sub>2</sub>O<sub>2</sub>), Hydroxyl radical (HO) Scavenging activity. The IC<sub>50</sub> value of <em>Glycyrrhiza glabra</em> is 120 µg/ml for DPPH<strong>, </strong>208 µg/ml for (NO), 196 µg/ml for (SO), 148 µg/ml for (H<sub>2</sub>O<sub>2</sub>), and 252 µg/ml for (OH). <em>Invitro </em>method suggests that <em>Glycyrrhiza glabra </em>is more powerful against nitric oxide and hydroxyl radicals. <strong>Conclusion: </strong>This preliminary study shows that <em>Glycyrrhiza glabra </em>is a promising herb with many phytochemicals and antioxidants it can be further investigated for its antiobesity potential.<strong></strong></p><p><strong>Key words: </strong><em>Glycyrrhiza glabra L.,</em> phytochemicals, antioxidant and obesity.</p>}, number={6}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={i, Archana and VIJAYALAKSHMI K}, year={2016}, month={Nov.}, pages={85–90} }