@article{Fathy_Latif_El-khayat_Moustafa_Farrag_Farahat_2016, title={EVALUATION OF CYCLIC ADENOSINE MONOPHOSPHATE AND NEUROTRANSMITTERS IN EXPERIMENTAL OBESITY: IMPACT OF BLACK PEPPER AND COFFEE AQUEOUS EXTRACTS}, volume={9}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/14592}, DOI={10.22159/ajpcr.2016.v9s3.14592}, abstractNote={<p>ABSTRACT<br />Objective: This study aims to evaluate the effect of black pepper and coffee extracts on chronic and acute experimental-induced obesity and energy<br />homeostasis.<br />Methods: Rats were divided into 10 groups including control, high-fat diet (HFD), triton, HFD+triton, black pepper+HFD, black pepper+HFD+triton,<br />coffee+HFD, coffee+HFD+triton, mixture+HFD, and mixture+HFD+triton groups. Blood glucose, serum insulin, and insulin resistance were estimated.<br />Body mass index, food efficiency intake, and body weight gain were calculated. Lipid profile, liver and kidney functions were measured, serum and brain<br />cyclic adenosine monophosphate (cAMP) was estimated, and brain neurotransmitters were measured by high-performance liquid chromatography.<br />Furthermore, histopathology of liver was performed.<br />Results: Findings showed that blood glucose, insulin resistance, lipid profile, kidney and liver functions as well as brain cAMP and neurotransmitters<br />were significantly increased, concomitant with a significant decrease in insulin resistance and serum cAMP in both HFD and triton-induced obesity<br />groups compared to control.<br />Conclusion: Supplementation with black pepper extract, coffee extract, and a mixture of both significantly improved these findings. In conclusion,<br />black pepper and coffee extracts are overlooked as promising weight reduction and antihyperlipidemic agents.<br /><strong>Keywords</strong>: Energy homeostasis, Obesity, Black pepper extract, Coffee extract, Cyclic adenosine monophosphate, Neurotransmitters.</p>}, number={9}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={Fathy, Shadia and Latif, Yasmin Abdel and El-khayat, Zakaria and Moustafa, Maha and Farrag, Abdel Razik and Farahat, Aya}, year={2016}, month={Dec.}, pages={87–96} }