@article{M_K_S_W_D_P_2017, title={IN VITRO IMMUNOSTIMULATION ACTIVITY OF NIGELLA SATIVA LINN. AND PSORALEA CORYLIFOLIA LINN. SEEDS USING A MURINE MACROPHAGE CELL LINE}, volume={10}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/16227}, DOI={10.22159/ajpcr.2017.v10i3.16227}, abstractNote={<p>ABSTRACT<br />Objective: The aim of this study is to analyze the phytochemical constituents and the in vitro immunomodulatory potential of ethanol extract of<br />Nigella sativa and Psoralea corylifolia seeds.<br />Methods: Phytoconstituents in the ethanol extract of N. sativa and P. corylifolia seeds were analyzed using gas chromatography and mass spectrum<br />and their immunomodulatory activity was investigated in vitro by cell proliferation assay with J774A.1 cell line.<br />Results: Thirteen biochemical constituents have been identified with ethanol extract of N. sativa and nine from the P. corylifolia. The maximum relative<br />activity of 138.77±0.44% cell proliferation was expressed at 25 μg/ml by N. sativa and 80.70±0.42% of proliferation by P. corylifolia at 25 μg/ml.<br />Conclusion: The results suggest that the ethanol extract of the plant seeds have stimulating activity on macrophage cells and could be useful for<br />modulating immune functions.<br />Keywords: Immunomodulatory, Cell proliferation, Macrophage cell line, Nigella sativa, Psoralea corylifolia.</p>}, number={3}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={M, Sheik Noor Mohamed and K, Jaikumar and S, Marimuthu and W, John Wyson and D, Anand and P, Saravanan}, year={2017}, month={Mar.}, pages={329–332} }