@article{Winantari_Setyawan_Siswodihardjo_Soewandhi_2017, title={COCRYSTALLIZATION ACYCLOVIR-SUCCINIC ACID USING SOLVENT EVAPORATION METHODS}, volume={10}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/16369}, DOI={10.22159/ajpcr.2017.v10i6.16369}, abstractNote={<p><strong>Objective :</strong> The aim of this research is to prepare and characterize cocrystals of acyclovir through cocrystallization of acyclovir – succinic acid (AS) to improve the physical properties of the drug.  </p><p><strong>Methods :</strong> AS cocrystals was prepared using solvent evaporation method. The cocrystals were  characterized by Polarization Microscope, Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC),  Powder X-Ray Diffraction (PXRD), and Fourier Transform Infrared Spectroscopy (FTIR).</p><p><strong>Results :</strong> Physical characterization using polarization microscope and SEM showed the AS cocrystals have unique crystal habit and morphology. Phase diagram at molar ratio of 50% : 50% (acyclovir : succinic acid) showed a decrease in the melting temperature i.e 176.23 <sup>o</sup>C  in comparison with the melting point of the constituent  materials (acyclovir 253.53<sup> o</sup>C and succinic acid 187.29 <sup>o</sup>C).  The PXRD pattern of AS cocrystals (ethanol) exhibited new diffraction peaks at 2θ = 5.91; 9.16; and 13.40. Besides, cocrystals of AS (glacial acetic acid) indicated new peaks at  2θ = 5.98; 9.19; and 13.43.  Furthermore, there was a shift in the N-H, O-H and C=O.</p><p><strong>Conclusion :</strong> Cocrystallization of acyclovir-succinic acid (AS) in ethanol and glacial acetic acid were succesfully formed using solvent evaporation methods.</p><p> </p><p> </p>}, number={6}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={Winantari, Agnes Nuniek and Setyawan, Dwi and Siswodihardjo, Siswandono and Soewandhi, Sundono Nurono}, year={2017}, month={Jun.}, pages={91–94} }