@article{Routray_Mohanty_2017, title={EFFECT OF ORAL MOXONIDINE IN THE ATTENUATION OF THE HAEMODYNAMIC RESPONSES SEEN DURING LAPAROSCOPIC SURGERIES}, volume={10}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/16383}, DOI={10.22159/ajpcr.2017.v10i3.16383}, abstractNote={<p>ABSTRACT<br />Objective: During laparoscopic surgeries, pneumoperitoneum can lead to various pathophysiologic changes in the cardiovascular system resulting in<br />hypertension and tachycardia. Search for ideal drug to prevent this hemodynamic response goes on. The aim of our study was to evaluate the effect of<br />orally administered moxonidine in attenuating the hemodynamic responses that occur during the laparoscopic surgeries.<br />Methods: A total of 50 adult acetylsalicylic acid I and II patients scheduled for elective laparoscopic surgeries were selected for this prospective<br />randomized double-blinded study. They were randomly allocated into two groups: moxonidine group (M) and placebo group (P). M group received<br />oral moxonidine 0.3 mg at 8 pm on the day before surgery and at 8 am on the day of surgery. P group received a placebo at the same timing as that of<br />the M group.<br />Results: Following pneumoperitoneum rise in systolic blood pressure (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and heart rate (HR)<br />was higher in P group in comparison to M group which was statistically significant.<br />Conclusion: Significant rise in HR, SBP, DBP, and mean BP was noted in the P group in comparison to moxonidine group. Moxonidine provided better<br />perioperative hemodynamic stability in patients undergoing laparoscopic surgeries.<br />Keywords: Moxonidine, Stress response, Laparoscopic.</p>}, number={3}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={Routray, Sidharth Sraban and Mohanty, Ramakanta}, year={2017}, month={Mar.}, pages={409–411} }