@article{S_S_Tp_Viswanad_2017, title={DESIGN AND INVITRO CHARACTERIZATION OF METFORMIN LOADED RESEALED ERYTHROCYTES}, volume={10}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/16636}, DOI={10.22159/ajpcr.2017.v10i4.16636}, abstractNote={<p><strong>Objective:</strong> Metformin is an oral antidiabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes. The<br />objective of this study was to retard the release of metformin using carrier erythrocyte for getting a parenteral slow release depot formulation.<br /><strong></strong></p><p><strong>Methods:</strong> The study retards the release of metformin by encapsulating in carrier erythrocyte. Endocytosis is the method used for the encapsulation<br />of the drug metformin.<br /><strong></strong></p><p><strong>Results:</strong> The optimized formulation shows 98.34% of drug release within 12 days. From the in vitro release data, zero order kinetic graph shows the<br />best fit graph. % cell recovered was found to be 73-78% and it suggests that the loading technique was less destructive.<br /><strong></strong></p><p><strong>Conclusion:</strong> The optimized formulation is a perfect carrier for the parenteral slow release depot of metformin.<br /><strong></strong></p><p><strong>Keywords:</strong> Resealed erythrocytes, Cross-linking, Cell recovery, Endocytosis, Slow release depot formulation.</p>}, number={4}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={S, Aiswarya and S, Parvathy and Tp, Aneesh and Viswanad, Vidya}, year={2017}, month={Apr.}, pages={231–238} }