@article{Roopashree_Mohan_Swaroop_Jagadish_RANGAPPA_2014, title={Synthesis, characterization and in vivo biological evaluation of novel benzimidazoles as potential anticancer agents}, volume={7}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/1875}, abstractNote={<p><strong>Objective: </strong>Cancer is one of the major cause of death worldwide irrespective of the sex. The aim of the study is to design, synthesize and identification of novel anti-proliferative agents that can potently target cancer.</p><p><strong>Methodology:</strong> We are reporting the synthesis of new series of N-substituted 2-(2-butyl-4-chloro-1<em>H</em>-imidazole-5-yl)-1<em>H</em>-benzo[d]imidazole derivatives and evaluated for their anti-tumor activity against HeLa cell lines. We identified the lead compound in the series and tested its anti-proliferative and anti-angiogenic properties against EAT bearing mice.</p><p><strong>Results:</strong> We identified 2-(2-butyl-4-chloro-1-heptyl-1H-imidazol-5yl)-1H-benzo[d]imidazole as a lead compound with the IC<sub>50</sub> of 25.3 µM. The lead compound is significantly decreases angiogenesis in peritoneum of EAT bearing mice.</p><strong>Conclusion:</strong> Our results clearly demonstrates that benzimidazoles suppresses the cell proliferation, peritoneal angiogenesis and ascites volume.}, number={5}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={Roopashree, Rangaswamy and Mohan, Chakrabhavi Dhananjaya and Swaroop, Toreshettahally Ramesh and Jagadish, Swamy and RANGAPPA, KANCHUGARAKOPPAL SUBBEGOWDA}, year={2014}, month={Nov.}, pages={309–313} }