@article{K_Noor Mohamed_W_M_A_D_P_2017, title={IN SILICO DOCKING ANALYSIS OF BIOACTIVE COMPOUNDS FROM CALOPHYLLUM INOPHYLLUM L. ETHANOL LEAF EXTRACT AGAINST EGFR PROTEIN}, volume={10}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/18972}, DOI={10.22159/ajpcr.2017.v10i8.18972}, abstractNote={<p><strong>Objective: </strong>The objective of this study was to evaluate the effective new phytocomponents from <em>Calophyllum inophyllum </em>ethanol leaf extract against breast cancer target protein of Epidermal Growth Factor Receptor (EGFR) using <em>in silico </em>docking studies.</p><p><strong>Materials and Methods: </strong>The identification of compounds was done by GC-MS analysis. The <em>in silico </em>docking studies were carried out using Discovery Studio 4.0 software.</p><p><strong>Results: </strong>The GC-MS analysis of ethanol leaf extract revealed the presence of eleven compounds. The docking analysis have exhibited moderate to potent inhibition with a range of dock score 3 to 55. 2H-Benzo(cd) pyrene-2,6(1,H)-dione, 3,5,7,10-tetrahydroxy-compound showed the dock score of 55.427.</p><p><strong>Conclusion: </strong>The results revealed out that the compounds present in <em>Calophyllum inophyllum </em>can inhibit the EGFR protein. The plant possesses anticancer potential because of the various bioactive compounds presence which is mainly responsible for anticancer activity.</p><p><strong> </strong></p>}, number={8}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={K, Jaikumar and Noor Mohamed, Sheik and W, John Wyson and M, Deventhiran and A, Babu and D, Anand and P, Saravanan}, year={2017}, month={Aug.}, pages={214–219} }