@article{Sari_Anggraini_2018, title={HISTOPATHOLOGICAL LIVER TISSUES OF ALLOXAN-INDUCED WISTAR RATS THAT GIVEN LAWSONIA INERMIS (LINN.) LEAVES’ ETHANOLIC EXTRACT}, volume={11}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/25358}, DOI={10.22159/ajpcr.2018.v11i8.25358}, abstractNote={<p class="Pa7"><strong>Objectives: </strong>The aim of this research was to see the effect of <em>Lawsonia inermis </em>(Linn.) leaves ethanolic extract (LLEE) on liver histopathological of alloxan-induced Wistar rats.</p><p class="Pa7"><strong>Methods: </strong>Thirty-five of male Wistar rats grouped into five groups, i.e., K (normal) given 0.9% NaCl solution and P1–P4 were induced using alloxan (120 mg/kg BW) intraperitoneally. P2–P4 was given LLEE, i.e., 200 mg/kg BW, 400 mg/kg BW, and 600 mg/kg BW for 28 days. On 29th day, all Wistar rats of the group were sacrificed to take its liver. Histology preparation of liver by paraffin slicing method of hematoxylin-eosin staining. The observation was done under a microscope with ×40 and ×100 magnification. Observation of the liver histopathological includes changes of the central venous, sinusoid, hepatocyte morphology, and glycogen accumulation, P1–P4 compared to K.</p><p class="Pa7"><strong>Result: </strong>The results showed that in P4 group, LLEE dose 600 mg/Kg BW for 28 days able to improve liver tissues structure of alloxan-induced Wistar rats.</p><p><strong>Conclusion: </strong>The LLEE at dose 600 mg/Kg BW effective can restore the liver destruction of alloxan-induced Wistar rats.</p>}, number={8}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={Sari, Mutiara Indah and Anggraini, Dwi Rita}, year={2018}, month={Aug.}, pages={162–165} }