@article{Rajan Abhinaya_Padmini_2019, title={BIOFABRICATION OF ZINC OXIDE NANOPARTICLES USING PTEROCARPUS MARSUPIUM AND ITS BIOMEDICAL APPLICATIONS}, volume={12}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/28682}, DOI={10.22159/ajpcr.2019.v12i1.28682}, abstractNote={<p class="Pa7"><strong>Objective: </strong>The objective of the study is to perform the synthesis of zinc oxide nanoparticles using the bark extract of <em>Pterocarpus marsupium </em>and to evaluate its biomedical applications.</p><p class="Pa7"><strong>Methods: </strong>Various concentrations of zinc acetate are used, and synthesis conditions were optimized to get a stable nanoparticle. The finest synthesis condition for zinc oxide nanoparticle production was at pH 7 with 20 ml extract, zinc acetate 10 mM, and 120 min of reaction time. The synthesized nanopowder was characterized using various analytical techniques, such as ultraviolet (UV)-visible spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM). The synthesized nanoparticles were tested for their antimicrobial, anti-inflammatory, inhibition of lipid peroxidation, and inhibition of amylase activity.</p><p class="Pa7"><strong>Results: </strong>The size range of nanoparticles obtained was in the range of 10–32 nm as reported by SEM. The UV-visible absorption spectrum of the synthesized nanoparticle showed a peak at 340 nm, which confirmed the presence of nanoparticles. FTIR spectroscopy analysis indicated the presence of zinc oxide stretching at 666.22 cm-1. Further, the IR spectra indicated the presence of alcohols and acids, which can act as capping agents around the nanoparticles. XRD analysis confirmed the crystalline nature of nanoparticles.</p><p class="Pa7">The synthesized nanoparticle showed appreciable antimicrobial activity. Zinc oxide nanoparticles at 40 μg/well were tested against phytopathogens, <em>Pseudomonas aeruginosa</em>, <em>Staphylococcus aureus, Aspergillus flavus, </em>and <em>Aspergillus niger </em>showed 16, 13, 15, and 16 mm zones of inhibition, respectively. The synthesized nanoparticle showed a considerable increase in inhibition of lipid peroxidation and amylase activity. The nanoparticle also exhibited appreciable anti-inflammatory activity measured by the inhibition of albumin denaturation.</p><p><strong>Conclusion: </strong>The study instigates the simple and convenient method of synthesizing zinc oxide nanoparticles using <em>P. marsupium </em>and its few biomedical applications.</p>}, number={1}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={Rajan Abhinaya, Shymala and Padmini, Ramakrishnan}, year={2019}, month={Jan.}, pages={245–249} }