@article{AMRULLAH SHIDIKI_BIJAY RAJ PANDIT_ASHISH VYAS_2019, title={Characterization and Prevalence of Clindamycin Resistance Staphylococcus aureus from Clinical samples of National Medical College and Teaching Hospital, Nepal}, volume={12}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/32257}, DOI={10.22159/ajpcr.2019.v12i5.32257}, abstractNote={<p><strong>Objective: </strong>Clindamycin is the drug of choice for the treatment of severe form of skin, soft tissue, and blood infections caused by resistant <em>Staphylococcus aureus </em>in the form of methicillin-resistant <em>S. aureus </em>(MRSA) and erythromycin-resistant <em>S. aureus</em>. In this research, we determine the susceptibility pattern of isolated <em>S. aureus </em>strains against antibiotics and the prevalence of resistant <em>S. aureus </em>in the form of MRSA, inducible clindamycin-resistant <em>S. aureus </em>(inducible macrolide-lincosamide-streptogramin B [iMLSB]) and constitutive clindamycin-resistant <em>S. aureus </em>(cMLSB).</p> <p><strong>Methods: </strong>A total of 310 isolated <em>S. aureus </em>among 2000 different clinical samples were subjected to oxacillin (1 μg) as per the Kirby-Bauer disk diffusion method for MRSA. Clindamycin-resistant either in the form of iMLSB or cMLSB was determined through double disk diffusion method or D-test by use erythromycin (2 μg) and clindamycin (15 μg) as per the CLSI guidelines.</p> <p><strong>Results: </strong>Out of total <em>S. aureus</em>, MRSA and methicillin-sensitive <em>S. aureus </em>(MSSA) were 78.06% and 20.64%, respectively. This study showed that iMLSB and cMLSB were 34.19% and 23.22%. Both iMLSB and cMLSB were found more among MRSA than MSSA (43.80%, 26.85% and 40.62%, 10.93%), respectively.</p> <p><strong>Conclusion: </strong>This study helps for the characterization of different resistant strains of <em>S. aureus </em>along with the determination of the prevalence rate of these mutant forms causing nosocomial infections.</p>}, number={5}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={AMRULLAH SHIDIKI and BIJAY RAJ PANDIT and ASHISH VYAS}, year={2019}, month={May}, pages={90–92} }