@article{GIRIJA R_ARUNA S_SANGEETHA R_2019, title={IN SILICO DOCKING ANALYSIS OF YOHIMBINE ALKALOIDS FROM CATHARANTHUS ROSEUS AGAINST DENGUE FEVER: Insilico Docking Studies}, volume={12}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/32815}, DOI={10.22159/ajpcr.2019.v12i5.32815}, abstractNote={<p><strong>Objective: </strong>In this docking study was performed by the active site of NS2B-NS3 protease with selected plant alkaloids derived from <em>Catharanthus roseus</em>. On the basis of docking results, out of the nine alkaloids yohimbine might be considered as the best inhibitors of NS2B-NS3 protease protein.</p> <p><strong>Methods: </strong>Lipinski rule was employed to check the ligand likeliness of the compound. The three-dimensional crystallographic structure of NS2B-NS3 protease (ID.2FOM) fetched from the protein data bank. The <em>in silico </em>docking studies were performed by “AutoDock version 4.2” software tool.</p> <p><strong>Results: </strong>Yohimbine is having the best binding score (−7.18 Kcal/mol) than the other eight compounds.</p> <p><strong>Conclusion: </strong>Hence, it has been concluded yohimbine as a novel inhibitor for NS2B-NS3 protease in dengue fever.</p>}, number={5}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={GIRIJA R and ARUNA S and SANGEETHA R}, year={2019}, month={May}, pages={344–354} }