@article{MEGHASHREE K S_LATHA K P_VAGDEVI H M_AJISH A D_JAYANNA N D_ARUNKUMAR N C_2020, title={SCREENING OF PHYTOCHEMICAL CONTENT AND IN VITRO BIOLOGICAL INVESTIGATION OF CANTHIUM DICOCCUM (GAERTN.) AND AMISCHOPHACELUS AXILLARIS (L.)}, volume={13}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/36200}, DOI={10.22159/ajpcr.2020.v13i1.36200}, abstractNote={<p><strong>Objective: </strong>The objective of the study was to study the pet ether, ethyl acetate, and ethanol leaf extracts of <em>Canthium dicoccum </em>and <em>Amischophacelus axillaris </em>for anthelmintic activity and antihypertensive activity.</p> <p><strong>Methods: </strong>The antihypertensive activity was carried out by employing a colorimetric assay based on the hydrolysis of Histidyl-Hippuryl-Leucine and anthelmintic activity carried out against Indian earthworm <em>Pheritimaposthuma</em>.</p> <p><strong>Results: </strong>The pet ether leaf extract both the plants exhibited the maximum antihypertensive activity with a percent inhibition of 64.82 for <em>C. dicoccum </em>(<em>Gaertn.</em>) and 84.12 for <em>A. axillaris </em>(<em>L.</em>) as compared with Captopril showing percent inhibition 85.37 and for anthelmintic activity, it is found that ethanol extract of <em>C. dicoccum </em>and ethyl acetate extract of <em>A. axillaris </em>exhibited significant activity against the standard drug albendazole.</p> <p><strong>Conclusion: </strong>This study investigated the potential of <em>C. dicoccum </em>and <em>A. axillaris </em>as a new source against the antihypertensive activity. The outcome of anthelmintic activity revealed that the ethyl acetate and ethanol extracts exhibited a considerable amount of anthelmintic activity, which is mainly due to the active phytoconstituents present in the extracts.</p>}, number={1}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={MEGHASHREE K S and LATHA K P and VAGDEVI H M and AJISH A D and JAYANNA N D and ARUNKUMAR N C}, year={2020}, month={Jan.}, pages={109–114} }