@article{BOUARFA_SOUIRTI_CERRUTI_AVELLA_FARAH_BOUSTA_2020, title={ANTI-OBESITY EFFECT OF CANNABIS SATIVA SEED FLOUR FROM KHLALFA OF TAOUNATE REGION (NORTHERN OF MOROCCO) IN HIGH CALORIC DIET-INDUCED OBESE MICE}, volume={13}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/39304}, DOI={10.22159/ajpcr.2020.v13i11.39304}, abstractNote={<p><strong>Objective: </strong>The objective of the present study was to evaluate the anti-obesity activity of <em>Cannabis sativa </em>seed Flour (CSSF) on obese mice.</p> <p><strong>Methods: </strong>The experiment process was carried out in 8 weeks. In this time, three groups of animals were adopted: High caloric diet control group (HCD), group treated with 100 mg/kg of CSSF, group treated with 200 mg/kg of CSSF, and normal diet control group (ND). Then, the histopathological and biochemical parameters analysis has been realized at the end of the experiment.</p> <p><strong>Results: </strong>As a result, body weight gain, epididymal, and perirenal adipose tissue decreased in the CSSF (<em>Cannabis sativa </em>seed Flour) group in both doses (100 mg/kg and 200 mg/kg) compared to the HCD. CSSF lowered serum glucose level elevated by HCD. For lipid profiles, total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, and triglycerides (TG) significantly decreased in the CSSF group. The histopathological results of this study showed a regenerative effect of CSSF on the kidney and liver tissues.</p> <p><strong>Conclusion: </strong>It is concluded from the present study that CSSF can be used as a natural anti-obesity agent.</p>}, number={11}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={BOUARFA, MOUNA and SOUIRTI, ZOUHAIR and CERRUTI, PIERFRANCESCO and AVELLA, MAURIZIO and FARAH, ABDELLAH and BOUSTA, DALILA}, year={2020}, month={Nov.}, pages={139–144} }