@article{Setyawan_Kusuma WARDHANA_Sari_2015, title={SOLUBILITY, DISSOLUTION TEST AND ANTIMALARIAL ACTIVITY OF ARTESUNATE NICOTINAMIDE CO CRYSTAL PREPARED BY SOLVENT EVAPORATION AND SLURRY METHODS}, volume={8}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/4332}, abstractNote={<p>Objective: The aims of this study was to investigate the solubility, dissolution rate and antimalarial activity against Plasmodium berghei of<br />artesunate (AR)-nicotinamide co-crystal prepared by solvent evaporation (CoSE) and slurry (CoS) method.<br />Methods: Co-crystals of AR-nicotinamide prepared by solvent evaporation and slurry methods were tested for solubility, dissolution rate and activity<br />of antimalarial compared to pure AR and physical mixture (PM) of AR and nicotinamide. Solubility test was conducted in distilled water at 37±0.5°C<br />and dissolution test was done in distilled water medium at 37±0.5°C using paddle stirrer. Antimalarial activity test was carried out on female mice<br />infected by P. berghei then parasitemia was observed.<br />Results: The AR solubility of slightly increased from 1236.66±141.42 to 1368.46±49.17 mg/L. Dissolution data at 30 minutes respectively for AR,<br />PM, CoS and CoSE (76.51±14.93; 75.45±18.07; 85.14±12.94 and 123.24±7.68%). The results were antimalarial activity test of P. berghei showed that<br />percent inhibition 84.98-89.50%. These data showed no significant differences in antimalarial activity between AR, CoS and CoSE.<br />Conclusions: Co-crystal AR nicotinamide prepared by solvent evaporation and slurry methods could increase the dissolution rate of AR in distilled<br />water medium compared to pure AR. Co-crystal AR nicotinamide prepared by solvent evaporation was not significant difference as antimalarial<br />activity in P. berghei compared to pure AR.<br />Keywords: Artesunate, Nicotinamide, Co-crystal, Solvent evaporation method, Slurry method, Dissolution rate, Antimalarial activity.</p><p><strong> </strong></p>}, number={2}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={Setyawan, Dwi and Kusuma WARDHANA, Narendra and Sari, Retno}, year={2015}, month={Mar.}, pages={164–166} }