@article{VARADHAN_SIMON A_2015, title={RATIO OF TRIGLYCERIDES TO HIGH-DENSITY LIPOPROTEIN CHOLESTEROL AND MARKERS OF LIVER INJURY IN DIABETES MELLITUS}, volume={8}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/8233}, abstractNote={<p>Objectives: The present study was done to evaluate and compare the triglyceride to high-density lipoprotein (TG/HDL) ratio in subjects with diabetes<br />mellitus (DM) and diabetic prone subjects (impaired glucose tolerance [IGT]) with normal subjects without diabetes. An attempt was also made to<br />correlate TG/HDL with markers of liver injury such as alanine aminotransferase, aspartate aminotransferase, (AST), and alkaline phosphatase (ALP).<br />Methods: Lab data of 496 patients attending Pushpagiri medical health checkup were obtained. The subjects were grouped into DM: (fasting plasma<br />glucose >126 mg/dl), IGT: (Fasting plasma glucose: 110-126 mg/dl) and normal: (fasting plasma glucose < 110 mg/dl).<br />Results: Statistically significant difference were observed in levels of TG, low-density lipoprotein (LDL), TG/HDL ratio, AST, ALP between diabetes, IGT<br />and normal subjects. Statistical significance within the groups was tested using post-hoc Analysis. The level of TG and TG/HDL ratio was significantly<br />higher in subjects with DM compared to normal subjects. The mean value of total cholesterol and LDL-C was found to be higher in normal subjects<br />than in DM and IGT. AST, ALP values were found to be significantly higher in subjects with IGT than normal subjects.<br />Conclusion: From this study, it can be concluded that TG and TG/HDL ratio were high in DM and IGT than subjects with normal plasma glucose. Liver<br />injury marker enzymes were found to be high in IGT and is correlated with TG/HDL ratio in DM.<br />Keywords: Diabetes mellitus, Impaired glucose tolerance, Hypertriglyceridemia, Triglyceride to high-density lipoprotein ratio, Markers of liver injury.</p>}, number={6}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={VARADHAN, SOWMYA and SIMON A, SUPRIYA}, year={2015}, month={Nov.}, pages={199–201} }