@article{P_NG_2016, title={FORMULATION AND EVALUATION OF VALSARTAN FAST DISINTEGRATING TABLETS BY VACUUM DRYING TECHNIQUE}, volume={9}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/9358}, abstractNote={<p>ABSTRACT<br />Objective: The main objective present research work an attempt has been made to prepare fast dissolving tablets of Valsartan by using vacuum<br />drying technique. Camphor, Urea and Menthol are used as a sublimating agent. Valsartan is an oral antihypertensive agent, with problems of variable<br />bioavailability and bioequivalence related to its poor water solubility. Valsartan is an angiotensin II type 1 receptor antagonist indicated in the<br />treatment of hypertension. <br />Methods: The prepared tablets Valsartan fast dissolving tablets were evaluated for various parameters like weight variation, hardness, friability,<br />disintegration time, drug content, water absorption ratio, wetting time, in- vitro drug release, FTIR, DSC studies and short term stability studies. The<br />blend was examined for the pre-compressional and post-compressional parameter. <br />Results and Discussions: The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing<br />property. All the post-compressional parameter are evaluated were prescribed limits and results were within IP acceptable limits. Based on the invitro<br />disintegration<br />time and dissolution studies formulations<br />SC2 and<br />SC3<br />were<br />found<br />to<br />be promising<br />and<br />showed<br />a<br />disintegration<br />time of 24<br />sec</p><p>and<br />16 sec<br />respectively.<br />Formulation<br />SC3 containing<br />camphor showed<br />highest<br />drug release<br />99.4% within<br />10 min.<br />IR spectral<br />analysis<br />and<br />DSC study</p><p>showed<br />that<br />there<br />was<br />no drug interaction<br />with formulation<br />additives<br />of<br />the<br />tablet as<br />there<br />is no<br />variation<br />and shift in<br />the position of<br />characteristic</p><p>absorption<br />bands it can<br />be<br />justified<br />there<br />is no interaction<br />between<br />drug and polymer.<br />Short term<br />stability studies<br />on the formulations<br />indicated<br />that<br />there<br />are<br />no significant change in hardness,<br />friability,<br />drug content<br />and in-vitro<br />drug release<br />(p<0.05). <br />Conclusion: The results concluded that fast dissolving tablets of Valsartan showing enhanced dissolution may lead to improved bioavailability<br />and effective therapy by using sublimation method.<br />Keywords: Fast dissolving tablet, Valsartan, Crospovidone, Camphor, Urea, Disintegration time.</p>}, number={2}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={P, Durga Bhavani and NG, RAGHAVENDRA RAO}, year={2016}, month={Mar.}, pages={73–79} }