TY - JOUR AU - Kn, Poornima AU - S, Kanimozhi AU - N, Karthick AU - A, Saravanan AU - R, Padmavathi PY - 2016/03/01 Y2 - 2024/03/29 TI - SKELETAL MUSCLE: ONE OF THE SILENT TARGETS OF DIABETIC COMPLICATIONS JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 9 IS - 2 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/10387 SP - 206-208 AB - <p>ABSTRACT<br />Objective: Muscle weakness in diabetes has been considered a rare manifestation associated with severe diabetic neuropathy. However, similar<br />findings are lacking in individuals with early diabetes. Handgrip strength is a reliable measurement of the disability index. The present study was<br />designed to determine the effect of early Type 2 diabetes on handgrip strength in adults by handgrip dynamometer.<br />Methods: 30 subjects with diabetes (1-5 years duration) were taken as case, and thirty age and sex-matched subjects without diabetes were taken<br />as controls. Subjects with hypertension, heart diseases, and neuromuscular disorders were excluded. Skeletal muscle function was determined using<br />hand grip dynamometer. Maximum voluntary contraction (MVC) was measured thrice and best of that it was taken. For endurance time (ET) 50% of<br />MVC was taken. Anthropometric measurements were taken, and random blood sugar testing was done.<br />Results: Compared to controls, cases had decreased mid forearm circumference (23.97±1.7 cm vs. 23.8±2.7 cm, p&lt;0.005). MVC and ET were also<br />significantly reduced in cases when compared with control subjects (MVC, 32.46±6.865 kg vs. 22.48±4.420 kg, p&lt;0.025) and ET (44.57±17.294 seconds<br />vs. 16.63±9.810 seconds, p&lt;0.022).<br />Conclusion: Our study suggests that there is a decline in skeletal muscle strength in type 2 diabetes even before the disease manifests severely.<br />This provides evidence that impaired grip strength is associated with adverse metabolic profile, in addition, to the loss of physical function, and the<br />potential for grip strength to be used in the clinical setting needs to be explored.<br />Keywords: Skeletal muscle function, Handgrip, Diabetes, Endurance time, Maximum voluntary contraction.</p> ER -