TY - JOUR AU - Masih, Manisha AU - Mittal, Abhilasha AU - Nandy, B.c. PY - 2014/09/01 Y2 - 2024/03/29 TI - SPECTROPHOTOMETRIC SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND LOSARTAN POTASSIUM IN TABLET DOSAGE FORMS JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 7 IS - 4 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/1280 SP - 61-63 AB - <p>Amlodipine (AML) besylate and losartan potassium (LSP) are used for the treatment of hypertension. A binary mixture of AML besylate and LSP was<br />determined by UV spectroscopic methods. The major aim of this research work was to develop simple, economical, accurate, and precise methods<br />for simultaneous estimation of AML and LSP in tablet dosage form. The method involved to solve simultaneous equations based on measurement of<br />absorbance at two wavelengths 240 nm (λ max of AML) and 220 nm (λ max of LSP). The two drugs followed beers-lamberts law over the concentration<br />range of 2 μg/ml-30 μg/ml for both the drugs (AML and LSP). The accuracy and precision of the methods were determined, and the methods validated<br />statically and this technique may be employed to analyze the drug containing AML besylate and LSP.</p><p>Keywords: Amlodipine besylate, Losartan potassium, UV spectroscopy, Simultaneous equation method.</p> ER -