TY - JOUR AU - UMASANKAR.K, AU - NAMBIKKAIRAJ, BALWIN AU - BACKYAVATHY.D, MANLEY PY - 2013/07/01 Y2 - 2024/03/29 TI - WOUND HEALING ACTIVITY OF TOPICAL MENTHA PIPERITA AND CYMBOPOGAN CITRATUS ESSENTIAL OIL ON STREPTOZOTOCIN INDUCED RATS JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 6 IS - 3 SE - Articles DO - UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/158 SP - 180-183 AB - <p>A common complication of diabetes is impaired wound healing. Systemic<em> Mentha piperita </em>and<em> Cymbopogan citratus </em> essential Â&nbsp;oil improves healing in diabetics, which is dose dependent, and may have side effects. There is a very less information regarding topical <em> Mentha piperita </em>and <em>Cymbopogan citratus </em>use. The objective of this study was to evaluate the effects of topical <em>Mentha piperita </em>and <em>Cymbopogan citratus </em>oil on wound healing.Â&nbsp; Diabetes was induced in wistar rats by using streptozotocin. The control group comprised age-matched animals not submitted to streptozotocin injection. Diabetic state was confirmed by glycosuria and hyperglycemia. Under tribromoethanol anesthesia, Diabetic induced infected wound treatment with topical <em>Mentha piperita</em> ointment treatment and their another essential ointment in <em>Cymbopogan citratus </em>wound contraction studies a circular piece 08 mm<sup>2 </sup>in area 20<sup>th</sup> days compared wound healing study onÂ&nbsp; theÂ&nbsp; woundÂ&nbsp; contractionÂ&nbsp; studies a circular piece 08mm<sup>2 </sup>in area 18<sup>th</sup> daysÂ&nbsp; highly effective in <em>Mentha piperita</em> ointment.Â&nbsp; Then non diabetic wound healing control on theÂ&nbsp; woundÂ&nbsp; contractionÂ&nbsp; studiesÂ&nbsp; a Â&nbsp;circular piece 07 mm<sup>2 </sup>in area12<sup>th</sup> days, complete wound healing activityÂ&nbsp; and diabetic woundÂ&nbsp;Â&nbsp; control compared with diabeticÂ&nbsp; infected wound treatment <em>Mentha piperita </em>ointmentÂ&nbsp; withÂ&nbsp; highly effectiveÂ&nbsp; wound healing activity histological, histometric and stereological methods were used for the analysis. Topical<em> Mentha piperitaÂ&nbsp;Â&nbsp; and Cymbopogan citratus </em>accelerated wound closure in diabetic and non-diabetic rats and the results were found to be more active than antibiotic treated controls. Topical <em> Mentha piperitaÂ&nbsp;Â&nbsp; and Cymbopogan citratus </em>could be helpful in diabetics, in order to improve the wound healing process avoiding possible adverse effects from systemic medication. All the values are statistically significant.</p><p><strong>Keywords:</strong></p><p>Topical <em>Mentha piperita </em>oil, <em>Cymbopogan citratus </em>oil, Wistar rats,Â&nbsp; Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;Â&nbsp;HematologicalÂ&nbsp; andÂ&nbsp; Histopathological factors, diabetesÂ&nbsp; wound healing.</p> ER -