TY - JOUR AU - Bharti, Umesh AU - Kumar, Neelima R AU - Kaur, Jaspreet PY - 2017/03/01 Y2 - 2024/03/29 TI - PROTECTIVE EFFECT OF BEE PROPOLIS AGAINST ANTI-TUBERCULOSIS DRUGS (RIFAMPICIN AND ISONIAZID)-INDUCED HEMATOLOGICAL TOXICITY IN SPRAGUE DAWLEY RATS JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 10 IS - 3 SE - Original Article(s) DO - 10.22159/ajpcr.2017.v10i3.15991 UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/15991 SP - 188-190 AB - <p>ABSTRACT<br />Objective: Protective effect of bee propolis against anti-tuberculosis (TB) drugs (rifampicin and isoniazid)-induced hematological toxicity in Sprague<br />Dawley (SD) rats.<br />Methods: Experimental male SD rats weighing 180±20 g were randomly assigned into eight groups (n=6), the Group 1 served as control; Group 2<br />received 200 mg bee propolis/kg body weight; Groups 3, 5, and 7 were treated with drugs 100 mg rifampicin/kg body weight, 50 mg isoniazid/kg<br />body weight, and 100 mg rifampicin+50 mg isoniazid/kg body weight, respectively. Groups 4, 6, and 8 were treatment groups receiving 200 mg bee<br />propolis/kg body weight+100 mg rifampicin/kg body weight, 200 mg bee propolis/kg body weight+50 mg isoniazid/kg body weight, and 200 mg bee<br />propolis/kg body weight+100 mg rifampicin+50 mg isoniazid/kg body weight, respectively. All the treatments were given for 30 days, and then, the<br />rats were sacrificed under light esthesia by cervical dislocation and blood was collected for physiological studies.<br />Results: Bee propolis supplementation (200 mg/kg body weight) showed increased level of hemoglobin with respect to rifampicin (15.45%),<br />isoniazid (11.34%), and rifampicin plus isoniazid (5.04%) administered groups after 30 days of treatment. Moreover, the decreased level of red blood<br />cell count and white blood cell count by anti-TB drugs rifampicin, isoniazid, and rifampicin plus isoniazid together was also elevated in treatment<br />group with bee propolis.<br />Conclusion: Coadministration of propolis (200 mg bee propolis/kg body weight) with drugs helped modulate the toxic effects by restoring tested<br />values to near normal.<br />Keywords: Propolis, Rifampicin, Isoniazid, Hemoglobin, Red blood cell count, White blood cell count.</p> ER -