TY - JOUR AU - Fadilah, Fadilah AU - Yanuar, Arry AU - Arsianti, Ade AU - Andrajati, Retnosari PY - 2017/03/01 Y2 - 2024/03/29 TI - PHENYLPROPANOIDS, EUGENOL SCAFFOLD, AND ITS DERIVATIVES AS ANTICANCER JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 10 IS - 3 SE - Review Article(s) DO - 10.22159/ajpcr.2017.v10i3.16071 UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/16071 SP - 41-46 AB - <p>ABSTRACT<br />Eugenol (EU) is a phenylpropene, an allyl chain-substituted guaiacol. EU is a member of the phenylpropanoids class of chemical compounds. It is a<br />colorless to pale yellow oily liquid extracted from certain essential oils especially from clove oil. Further, chemopreventive agents might be used singly<br />or in combination with chemotherapy or radiotherapy for the more effective treatment of cancer by enhancing the efficacy of these modalities with<br />minimal side effects and toxicity. Considering that EU scaffold may be a prospective chemopreventive agent, its potent antitumor ability to interfere<br />with solid cancer cell growth and its molecular mechanism were evaluated as an initiative toward the development of a novel strategy for cancer<br />treatment. This review article will conduct that EU as the antiproliferative activity and molecular mechanism of the EU induced apoptosis against the<br />cancer cells and animal models.<br />Keywords: Eugenol, Derivatives of eugenol, Scaffold, Anticancer, Phenylpropanoids.</p> ER -