TY - JOUR AU - Pariaputra, Jennifer Surja AU - Budiardjo, Sarworini Bagio AU - Suharsini, Margaretha PY - 2018/02/01 Y2 - 2024/03/29 TI - EFFECTS OF A PROBIOTIC MILK DRINK ON SALIVARY TUMOR NECROSIS FACTOR-ALPHA IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN THE INDUCTION PHASE JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 11 IS - 2 SE - Original Article(s) DO - 10.22159/ajpcr.2018.v11i2.23242 UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/23242 SP - 340-343 AB - <p class="Pa7"> <strong>Objective: </strong>The aim of this study was to investigate the effects of the short-term use of a probiotic milk drink on salivary tumor necrosis factor-alpha (TNF-α) in children with acute lymphoblastic leukemia (ALL) during the induction phase of chemotherapy.</p><p class="Pa7"><strong>Methods: </strong>A randomized, case-controlled clinical trial was carried out. The samples of the study were collected from 11 children with ALL and 11 healthy children as the control. Both groups received a probiotic milk drink. The probiotic milk drink contained <em>Lactobacillus casei </em>(6.5×109 colony forming unit/mL). The subjects were instructed to rinse 5 mL of probiotic milk drink for 30 s over the course of 2 weeks. Unstimulated saliva samples were collected from patients at baseline and 1 and 2 weeks after rinsing with the probiotic milk drink. The levels of TNF-α were determined using a human TNF-α enzyme-linked immunosorbent assay kit.</p><p class="Pa7"><strong>Results: </strong>The salivary TNF-α levels in the experimental group decreased but not to a statistically significant degree (p&gt;0.05) when comparing the baseline with weeks 1 and 2 after rinsing. There was a significant decrease of salivary TNF-α levels in the control group (p&lt;0.05) when comparing the baseline with 1 and 2 weeks after rinsing. The concentration of salivary TNF-α in the experimental group was higher than in the control group (p&lt;0.05).</p><p><strong>Conclusion: </strong>This study demonstrates the effect of a short-term intake of a probiotic milk drink on children with ALL during the induction phase of chemotherapy. The results show a reduction of salivary TNF-α after taking the probiotic milk drink after 1 week and 2 weeks, although the results were not statistically significant.</p> ER -