TY - JOUR AU - G, Savitha AU - V, Vishnupriya AU - Krishnamohan, Surapaneni PY - 2018/07/07 Y2 - 2024/03/29 TI - IN VITRO ANTIOXIDANT CAPACITY AND FREE RADICAL SCAVENGING ACTIVITIES OF CARDIOSPERMUM HALICACABUM LINN. JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 11 IS - 7 SE - Original Article(s) DO - 10.22159/ajpcr.2018.v11i7.25044 UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/25044 SP - 421-426 AB - <p><strong>Objective: </strong>Free radicals and oxidants are produced in the body during normal cellular metabolism and exposure to pollutions and ionizing radiations. They exert beneficial and harmful effects to the human body. Harmful effects of these radicals are destroyed by either antioxidants of our body <em>in situ </em>or antioxidants which are supplied through foods. Hence, the aim of this present study is to assess the antioxidant and free radical scavenging capacity of the easily available edible plant <em>Cardiospermum halicacabum </em>Linn. (Mudakathan keerai).</p><p><strong>Methods: </strong>Antioxidant and free radical scavenging activities of the aerial parts extract of <em>C. halicacabum </em>was determined by 2,2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging assay, 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assay, ferrous ion chelating assay, nitric oxide (NO) radical scavenging assay, superoxide radical scavenging assay, hydroxyl radical scavenging assay, and lipid peroxidation assay.</p><p><strong>Results: </strong>Remarkable free radical scavenging potential was observed in the ethanolic extract of <em>C. halicacabum </em>with IC50 values on all tested radicals, namely DPPH (IC50=34.06 μg/ml), ABTS (IC50=21.45 μg/ml), ferrous ion chelating (IC50=19.56 μg/ml), NO (IC50=25.16 μg/ml), superoxide (IC50=35.16 μg/ml), hydroxyl (IC50=28.56 μg/ml), and lipid peroxidation (IC50=33.12 μg/ml). The results revealed that ethanolic extract of <em>C. halicacabum </em>Linn. has significant antioxidant activity.</p><p><strong>Conclusion: </strong>The present study suggested that the aerial part extract of <em>C. halicacabum </em>serves as a good source of natural antioxidants.</p> ER -