TY - JOUR AU - Pardede, Tuty Roida AU - Muchlisyam, Muchlisyam PY - 2018/04/26 Y2 - 2024/03/28 TI - ANALYSIS ON CALCIUM SOLUBILITY IN KIDNEY STONES (IN VITRO) AND DIURETIC EFFECT (IN VIVO) USING CORN SILK (ZEA MAYS L.) INFUSE JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 11 IS - 13 SE - Original Article(s) DO - 10.22159/ajpcr.2018.v11s1.26573 UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/26573 SP - 80-83 AB - <p class="Pa9"><strong>Objective: </strong>Investigation has been carried out about infuse of corn silk (<em>Zea mays </em>L.) concerning the solubility of kidney stone <em>in vitro </em>and the diuretic effect <em>in vivo. </em></p><p class="Pa9"><strong>Methods: </strong>The methodology of research conducted in the form of dissolving kidney stones in corn silk infuse with a concentration of 2%, 4%, 6%, 8%, and 10%, then incubated at 37°C for 4 h. The solubility of calcium is known by measuring the levels of early calcium and after incubated with kidney stones. Potassium (K) is a substance that can dissolve kidney stones in infuse and also measured by atomic absorption spectrophotometry. The diuretic effect study used male rats which were divided into 7 groups that consisted of 1 positive control (treated with furosemide), 1 negative control treated with CMC Na 0.5 % and 5 groups treated with infuse of corn silk in 5 different concentration (2%, 4%, 6%, 8%, and 10%).</p><p class="Pa9"><strong>Results: </strong>Increase in calcium levels after incubation with kidney stone using corn silk infuse with various concentrations. The levels of Ca dissolved in the infuse of 2%, 4%, 6%, 8%, and 10%, respectively, were 2.2600 μg/ml, 5.5733 μg/ml, 7.9267 μg/ml, 10.9233 μg/ml, and 8.7667 μg/ml. It was found that the urine volume for 24 h was significant with 2%, 8%, and 10% corn silk infuse.</p><p><strong>Conclusion: </strong>Infuse of corn silk could decrease kidney stones, and it was diuretic. This research supported the aim of traditional corn silk decoction for the same intention.</p> ER -