TY - JOUR AU - Bangun, Hakim AU - Aulia, Fadlina AU - Arianto, Anayanti AU - Nainggolan, Marline PY - 2019/01/07 Y2 - 2024/03/29 TI - PREPARATION OF MUCOADHESIVE GASTRORETENTIVE DRUG DELIVERY SYSTEM OF ALGINATE BEADS CONTAINING TURMERIC EXTRACT AND ANTI-GASTRIC ULCER ACTIVITY JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 12 IS - 1 SE - Original Article(s) DO - 10.22159/ajpcr.2019.v12i1.29715 UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/29715 SP - 316-320 AB - <p class="Pa7"><strong>Objectives: </strong>The objectives of this study were to prepare the mucoadhesive mucoadhesive gastroretentive drug delivery system of alginate beads containing turmeric extract and to evaluate its anti-gastric effect.</p><p class="Pa7"><strong>Methods: </strong>Turmeric extract was made by macerating turmeric powder in ethanol 96% and evaporated using rotary evaporator at 50°C to obtained concentrated extract. Then, it was prepared alginate beads containing 5% turmeric extract by gelation method. The mucoadhesive properties of alginate beads containing turmeric extract were tested <em>in vitro </em>in male rats and the anti-gastric ulcer effect was tested on HCl-induced gastric ulcer in rats.</p><p class="Pa7"><strong>Results: </strong>The mean diameter of alginate beads obtained was 1.13±0.19 mm. Bioadhesion test showed that alginate beads containing turmeric extract could be attached on gastric rats mucosa. Anti-gastric ulcer test showed that the healing of gastric lesions in rats was faster using alginate beads containing turmeric extract compared to untreated ones.</p><p><strong>Conclusions: </strong>The results of this study suggest that mucoadhesive drug delivery systems of alginate beads containing turmeric extract are potentially developed as an anti-gastric ulcer.</p> ER -