TY - JOUR AU - JYOTHI , BASINI AU - MOHANALAKSHMI, S. AU - K., ANITHA PY - 2013/08/01 Y2 - 2024/03/29 TI - PROTECTIVE EFFECT OF MIRABILIS JALAPA LEAVES ON ANTI-TUBERCULAR DRUGS INDUCED HEPATOTOXICITY JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 6 IS - 7 SE - Articles DO - UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/312 SP - 221-224 AB - <p><strong>Abstract</strong></p> <p><strong>Objectives: </strong>The present study was undertaken for investigating the protective effect of ethanolic extract of<em> Mirabilis Jalapa </em>Linn leaves on anti-tubercular drugs induced hepatotoxicity. <strong>Methods:</strong> Anti-tubercular drugs were used to induce hepatotoxicity. Ethanolic extract of leaves of <em>Mirabilis Jalapa </em>Linn (250 &amp; 500 mg/kg p.o.) was administered with one hour prior administration of anti-tubercular drugs once daily for 35 days. Silymarin was used as standard drug (100 mg/kg p.o.). <strong>Results:</strong> Liver biomarkers such as SGOT, SGPT, ALP, TB, total cholesterol were elevated and total HDL were reduced on anti-tubercular drugs administration. Pretreatment of ethanolic extract of leaves of <em>Mirabilis Jalapa </em>Linn 250 mg/kg and 500 mg/kg with anti-tubercular drugs were significantly reduced liver biomarker enzymes. Antioxidant parameters such as SOD, CAT, GSH, GPx and GRx were suppressed and increased TBARs levels in anti-tubercular drugs administration but restored these antioxidant levels in pretreatment of ethanolic extract of <em>Mirabilis Jalapa </em>Linn leaves at a dose of 250 mg/kg and 500 mg/kg. <strong>Conclusion:</strong> The result of the present study was indicated that <em>Mirabilis Jalapa </em>Linn showed hepatoprotective effect on hepatotoxicity induced by anti-tubercular drugs.</p> <p><em>Key Words:</em> Hepatoprotective activity, Anti-tubercular drugs, Liver biomarkers, <em>Mirabilis Jalapa, </em>Antioxidant parameters.</p> ER -