TY - JOUR AU - ZEROUAL, AHMED AU - ELOUTASSI, NOUREDDINE AU - CHAOUCH, MAHDI AU - CHAQROUNE, ABDELLAH PY - 2020/03/07 Y2 - 2024/03/28 TI - ANTIMICROBIAL, ANTIOXIDANT ACTIVITY, AND CHEMICAL COMPOSITION OF ORIGANUM COMPACTUM BENTH FROM TAOUNATE PROVINCE, NORTH MOROCCO JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 13 IS - 3 SE - Original Article(s) DO - 10.22159/ajpcr.2020.v13i3.36319 UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/36319 SP - 126-131 AB - <p><strong>Objective: </strong><em>Origanum compactum </em>is one of the most important medicinal species in terms of ethnobotany in Morocco. It attracts the attention of several research works; however, its chemical composition under local conditions is not well documented. Here, we aimed at determining essential oil chemical composition, antibacterial, and antioxidant activities of organic extracts of <em>O. compactum</em>.</p><p><strong>Methods: </strong>Antimicrobial activities were assessed against four strains (<em>Escherichia coli</em>, <em>Staphylococcus aureus</em>, <em>Bacillus subtilis</em>, and <em>Candida albicans</em>). Antioxidant activities were estimated by radical 2,2-diphenyl-1-picrylhydrazyl scavenging activity. Polyphenols and flavonoids were determined. Chemical composition was screened using gas chromatography.</p><p><strong>Results: </strong>Our results showed that yield extracts varied significantly among solvents and ranged from 10.30% (n-hexane) to 31.70% (methanolic). Methanolic extracts had the highest values of yield, polyphenols, and flavonoids, while n-hexane extracts showed the lowest values of yield and polyphenols. Regarding antimicrobial activities, <em>E. coli </em>showed the most important activity. Concerning antioxidant activities, n-hexane extracts had the most important activity. The phytochemical screening revealed 12 compounds. Among them, γ-Terpinene, o-Cymene, and carvacrol were the major compounds (around 73% of total chemical compounds).</p><p><strong>Conclusion: </strong>It could be concluded that the studied plant might be a promising source of chemical compounds responsible for important biological activities.</p> ER -