TY - JOUR AU - RABEQUE, C. SAVITHA AU - PADMAVATHY, S. PY - 2013/09/01 Y2 - 2024/03/29 TI - HYPOGLYCAEMIC EFFECT OF SYZYGIUM CARYOPHYLLATUM (L.) ALSTON ON ALLOXAN INDUCED DIABETIC ALBINO MICE JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 6 IS - 8 SE - Articles DO - UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/387 SP - 202-205 AB - <p>Objective: The primary objective of this study was to determine the hypoglycaemic activity of <em>S. caryophyllatum </em>in alloxan induced diabetic mice.</p><p>Methods: Alloxan was administered as a single dose (60mg/kg, b. wt) to induce diabetes. Methanol extracts from <em>S. caryophyllatum </em>(250mg/kg body weight/day) was administered for 14 days to alloxan induced diabetic mice and the body weight changes and fasting blood sugar levels were monitored on 0, 7<sup>th</sup> and 14<sup>th</sup> day. Glycosylated haemoglobin levels also estimated.</p><p> Result: The results suggest that the administration of <em>S. caryophyllatum </em>have hypoglycaemic activity in alloxan induced diabetic mice and their effect was equivalent to that of reference drug Glibenclamide. Conclusions: The results suggested that the methanol extract of S.<em> caryophyllatum</em> <em> </em>possess anti-diabetic effect on Alloxan induced diabetic mice and it can be recommended for the prevention of diabetes mellitus.</p><strong>Keywords:</strong> Alloxan monohydrate, Glibenclamide, Glycosylated haemoglobin ER -