TY - JOUR AU - A, SRUTHI AU - PRASAD PANIGRAHY, UTTAM PY - 2021/02/07 Y2 - 2024/03/28 TI - STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION OF FIMASARTAN BY REVERSE-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY IN BULK AND PHARMACEUTICAL DOSAGE FORM JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 14 IS - 2 SE - Original Article(s) DO - 10.22159/ajpcr.2021.v14i2.39919 UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/39919 SP - 138-146 AB - <p><strong>Objective: </strong>A rapid, sensitive and specific reverse phase High performance liquid Chromatography (RP-HPLC) method was developed for the estimation of Fimasartan in bulk and pharmaceutical dosage form.</p><p><strong>Method: </strong>The RP-HPLC analysis was performed isocratically on a Primacel C18 column (150 mm × 4.6 mm internal diameter, 5 μm particle size) using mobile phase of composition Acetonitrile and 0.1% orthophosphoric Acid in 80:20, v/v proportions with a flow rate of 0.8 ml/min.</p><p><strong>Results: </strong>The analyte was monitered with UV-detector at 265 nm. In the developed method Fimasartan elutes at a typical retention time of 2.4 min. The proposed method is having linearity in the concentration ranging from 5-30 μg/ml of Fimasartan.</p><p><strong>Conclusion: </strong>: The method was statistically validated and had been applied to analysis of the drug in bulk and pharmaceutical dosage form.</p> ER -