TY - JOUR AU - Itankar, Prakash R PY - 2013/11/01 Y2 - 2024/03/28 TI - EFFECT OF MEDICATED OIL OF MARTYNIA ANNUA LEAVES AND FRUITS ON TESTOSTERONE INDUCED ALOPECIA IN MICE JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 6 IS - 9 SE - Articles DO - UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/489 SP - 49-52 AB - <p><strong>Objective</strong>: The present study aims to evaluate the hair growth promoting activity of leaves and fruits of <em>Martynia annua</em> in testosterone induced alopecia in mice.</p><p><strong>Methods:</strong> Medicated oils of <em>Martynia annua</em> leaves and fruits were prepared for topical application as per process mentioned in Ayurveda. Alopecia was induced in albino mice by testosterone (1 percent w/w) administration subcutaneously for 20 days. Its inhibition by simultaneous administration of medicated oils prepared from leaves and fruits were evaluated using follicular density and anagen/telogen (A/T) ratio, wherein, Finasteride (5-alpha-reductase inhibitor) (0.2 percent) solution served as positive control.</p><p><strong>Results:</strong> Medicated oil of leaf extract of <em>Martynia annua</em> exhibited promising hair growth-promoting activity, as reflected from follicular density and A/T   ratio. The treatment was also found successful in bringing greater number of hair follicles in anagenic phase, when compared with control.</p><p><strong>Conclusion: </strong>Our results concluded that the medicated oil of leaf extract (MOLE) of <em>Martynia annua</em> plant shows excellent hair growth activity along with antiandrogenic activity in testosterone induced alopecia model as compared to standard Finasteride.<strong></strong></p> ER -