TY - JOUR AU - Eid, Ahmad M AU - Elnattah, Nabil AU - Elmahgoubi, Assad AU - Abdul Hamid, Mariani AU - Hasham, Rosnani AU - Aziz, Azila AU - Ariffin, Farah Diana AU - Salama, Mohamed m AU - Elmarzugi, Nagib A PY - 2015/07/01 Y2 - 2024/03/28 TI - USAGE OF SUGAR ESTER IN THE PREPARATION OF AVOCADO OIL NANOEMULSION JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 8 IS - 4 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/5285 SP - 66-69 AB - <p>ABSTRACT<br />Objectives: Due to the high dynamics of pharmaceutical products markets, developments of new products using latest innovative technology are<br />becoming a norm of many pharmaceutical companies. Nanoscale materials such as nanoemulsion (NE) offer advantages such as the controllable<br />droplet size, long-term stability, and power solubilization ability. It is beneficial in various delivery systems either for transdermal, ocular, nasal,<br />vaginal, and parenteral drug delivery. The objective of the study was to prepare avocado oil NE using different surfactants to find the most suitable<br />nanosized droplets, as avocado oil offers a variety of purported nutritional and medicinal benefits.<br />Methods: Sucrose esters, glycerol, and avocado oil with different ratio were used to produce pre-NE by phase inversion technique then pre-NE<br />were self-emulsified with water to produce NE. The influence of the sucrose esters surfactants on the NE formulations were determined using three<br />different types of sucrose esters surfactant (laureate, oleate, and palmitate). Stability study was conducted for NE at different temperatures (4°C, 25°C,<br />and 40°C) for 6 months.<br />Results: The NE contained sucrose laureate produced best nanosized formulations compared to other oleate and palmitate, with optimum droplet<br />size 106 ± 1.70 nm, size distribution 0.156 ± 0.01, and zeta potential −30.4 ± 0.70. The NE formulations were very stable at 4°C compared to 25°C and<br />40°C while at 25°C NE showed moderate stability, but it was unstable at 40°C.<br />Conclusion: Sucrose laureate was able to produce NE with phase inversion and self-emulsification techniques and the ideal storage condition for NE is 4°C.<br />Keywords: Avocado oil, Nanoemulsions, Self-nanoemulsification, Phase inversion technique, Sucrose ester, Stability.</p> ER -