TY - JOUR AU - T, RAJANANDA SWAMY AU - B, GANGA RAO AU - P, Haritha PY - 2015/07/01 Y2 - 2024/03/28 TI - ANTIOXIDANT ACTIVITY AND HEPATOPROTECTIVE POTENTIAL OF BALANITES ROXBURGHII FRUITS JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 8 IS - 4 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/6647 SP - 270-273 AB - <p>ABSTRACT<br />Objectives: The objective of the present study was to evaluate antioxidant activity and hepatoprotective potential of a hydroalcoholic extract of<br />Balanites roxburghii (BR) fruits.<br />Methods: Extraction was performed by triple maceration using ethanol:water as a solvent. The extracts were vaporated using rotavapor. Then<br />antioxidant capacities were tested using superoxide, hydroxyl, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. Determination of hepatoprotective<br />model was performed by thiocetamide induced liver models.<br />Results: The hydroalcoholic extract of BR fruits produced a dose-dependent percentage inhibition on tested free radicals, i.e., superoxide anion<br />(50% inhibition concentrations [IC50] value 190.50 μg/ml), hydroxyl radical (IC50 value 266.30 μg/ml), and DPPH radical (IC50 value 175 μg/ml). After<br />treatment with silymarin and hydroalcoholic extract of BR in respective groups, they had showed good protection against thioacetamide induced liver<br />toxicity.<br />Conclusion: The results of the present investigation clearly indicate the free radical scavenging activity and hepatoprotective potential of a<br />hydroalcoholic extract of BR fruits and this activity is comparable with that of the standard drugs ascorbic acid and silymarin.<br />Keywords: Balanites roxburghii, Antioxidant activity, Hepatoprotective activity, Ascorbic acid.</p> ER -