TY - JOUR AU - Debnath, Biplab AU - Ganguly, Swastika PY - 2015/09/01 Y2 - 2024/03/28 TI - SYNTHESIS, CHARACTERIZATION AND ANTHELMINTIC ACTIVITY OF ISATIN ANALOGS AGAINST PHERITIMA POSTHUMA JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 8 IS - 5 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/7083 SP - 150-155 AB - <p>bjective: Isatin (1H-indole-2,3-dione), an endogenous compound identified in many organisms, shows a wide range of biological activities. In view<br />of these facts, in our present communication, we wish to report the synthesis and evaluation of some isatin analogs for anthelmintic activity against<br />Pheritima posthuma.<br />Methods: A series of 16 isatin analogs (3a-3p) have been synthesized, characterized by physical and spectral data (Fourier transform infrared,<br />H<br />nuclear magnetic resonance and mass) and screened for anthelmintic activity against P. posthuma at various concentrations (5, 10, and 20 mg/ml).<br />Results: All compounds were tested for the beginning of paralysis time followed by a time of the death of worms. All prototypes at the concentration<br />of 20 mg/ml showed significant activity (p&lt;0.01) compared to that of control. The compounds 3f and 3i were found to possess significant activity<br />compared to standard albendazole (20 mg/ml).<br />Conclusion: The study encourages us to consider a new molecular skeleton of isatin substituted at the first and third position by aryl groups with<br />adequate spacers which may be identified as potential leads for the development of future studies in various in vivo models for anthelmintic activities.<br />Keywords: Isatin, Synthesis, Spectral analysis, Pheritima posthuma, Anthelmintic activity.</p> ER -