TY - JOUR AU - Kumar, Nitin AU - Chaudhary, Anurag PY - 2015/09/01 Y2 - 2024/03/29 TI - EVALUATION OF ANTHELMINTIC ACTIVITY OF PRUNUS PERSICA (L.) JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 8 IS - 5 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/7103 SP - 163-165 AB - <p><strong>Objective:<em> </em></strong><em>Prunus persica</em> leaves are used as anthelmintic, insecticidal, sedative, diuretic, demulcent, expectorant and vermicidal ethnopharmacologically. Objective of present study was evaluation of anthelmintic activity of different extracts of<em> Prunus persica</em> leaves.</p><p><strong>Methods:</strong><em> Pheretima posthuma</em> (annelids) and <em>Ascaridia galli</em> (nematods) were used to perform experiments for anthelmintic activity. Piperazine citrate was used as standard. Time required for paralysis and death (lethal time) of worms were noted for each sample of <em>P. persica</em> extracts and standard.</p><p><strong>Results:</strong> The results demonstrated that treatment with <em>Prunus persica</em> significantly (<em>P</em>&lt;0.05-<em>P</em>&lt;0.01) with dose-dependently paralyzed and killed the both A. galli and earthworms. Ethanol and ethyl acetate extracts have showed comparable anthelmintic activity at the highest concentration (60 mg/ml) to the well known anthelmintic agent Piperazine citrate against <em>A. galli</em>.</p><p><strong>Conclusion:<em> </em></strong>The ethanolic &amp; ethyl acetate extracts exhibited maximum potency i.e. shortest paralysis and lethal times. The potency was not more than the reference drug, piperazine citrate but comparable to it at 60 mg/ml concentrations in both test worms.<strong></strong></p><p><strong>Keywords: </strong><em>Prunus. Persica, </em>Anthelmintic activity,<em> Pheretima posthuma</em>, <em>Ascaridia galli</em>.</p> ER -