TY - JOUR AU - Ks, Rajesh AU - K, Ishwara Bhat AU - C, Vaman Rao PY - 2016/01/01 Y2 - 2024/03/28 TI - PRELIMINARY PHTOCEMICAL INVESTIGATION AND ANTI-VENOM ACTIVITY OF COIX LACRYMAJOBI ROOT EXTRACT AGAINST DABOIA RUSSELLI VENOM-INDUCED MYONECROSIS JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 9 IS - 1 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/9165 SP - 319-321 AB - <p>Objective: The aim of the study was to carry out the preliminary phytochemical investigation and to evaluate the inhibition of Daboia russelli<br />venom‑induced myonecrosis by root extract (RE) of Coix lacrymajobi.<br />Methods: The roots of C. lacrymajobi were subjected to differential extraction by soxhlet extraction using petroleum ether, chloroform, ethyl acetate,<br />and ethanol. The resultant extracts were subjected to the preliminary phytochemical investigation to identify the different chemical groups present in<br />the extracts. Myonecrotic activity was conducted, to assess the ability of ethanolic RE to inhibit the myonecrosis induced by D. russelli venom in rats.<br />Results: The preliminary phytochemical investigation revealed the presence of triterpenoids, resins, steroids and fixed oils in petroleum ether extract,<br />flavonoids, triterpenoids, saponins and fixed oils in chloroform extract and alkaloids, carbohydrates, flavonoids, glycosides, resins, saponins, steroids,<br />and tannins. Ethanolic extract was found to have maximum number of phytochemicals, and hence, it was used for further study. The ethanolic RE<br />significantly inhibited the myonecrotic activity at dose level 200 and 400 mg/kg body weight.<br />Conclusion: The screening of phytochemicals presents on the different fractions of the RE was studied successfully. Supporting the use of roots by<br />traditional healers, ethanolic extract successfully inhibited D. russelli venom‑induced myonecrosis in rats.<br />Keywords: Coix lacrymajobi, Daboia russelli, Myonecrosis.</p> ER -